网站主页 >> CAS数据库列表 >> N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
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- CAS号:
- 1428327-31-4
- 英文名:
- N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide
- 英文别名:
- JNJ-47965567;JNJ-479655;JNJ-47965567 >=98% (HPLC);JNJ-47965567
(JNJ47965567);N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE;N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide;Inhibitor,P2X7,JNJ-47965567,pain,JNJ 47965567,P2X Receptor,inhibit,neuropathic,JNJ47965567,P2XRs;2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide;3-Pyridinecarboxamide, 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-
- 中文名:
- N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
- 中文别名:
- 化合物JNJ-47965567;JNJ 47965567,P2X7拮抗剂;N-((4-(4-苯基哌嗪-1-基)四氢-2H-吡喃-4-基)甲基)-2-(苯硫基)烟酰胺
- CBNumber:
- CB83146923
- 分子式:
- C28H32N4O2S
- 分子量:
- 488.64
- MOL File:
- 1428327-31-4.mol
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N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE化学性质
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储存条件:
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2-8°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);61.39(Max Conc. mM)
DMSO:59.62(Max Conc. mg/mL);122.01(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM) Ethanol:12.5(Max Conc. mg/mL);25.58(Max Conc. mM)-
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形态:
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powder
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颜色:
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white to beige
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N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE性质、用途与生产工艺
JNJ-47965567 是一种中枢通透性、高亲和力、选择性的 P2X7 拮抗剂,对人和大鼠 P2X7 作用的 pKi 值分别为 7.9 和 8.7。JNJ-47965567 可用于探讨中枢 P2X7 在中枢神经系统病理生理模型中的作用。
pKi: 7.9 (huaman P2X7), 8.7 (rat P2X7)
JNJ-47965567 exhibits high affinity for human and rat P2X7 in membrane preparations of 1321N1 cells.
JNJ-47965567 does not block IL-6 and TNF-α release, under identical conditions (LPS and BZ-ATP) used for IL-1β and IL-18 release.
JNJ-47965567 attenuates IL-1β release with pIC
50
s of 6.7 ± 0.07 (human blood), 7.5 ± 0.07 (human monocytes) and 7.1 ± 0.1 (rat microglia), respectively, in native systems.
JNJ-47965567 (30-100 mg/kg; s.c.) attenuates IL-1β release induced by Bz-ATP.
JNJ-47965567 (30 mg/kg) attenuates amphetamine-induced hyperactivity and exhibits modest, yet significant efficacy in the rat model of neuropathic pain.
Animal Model:
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Male Sprague Dawley rats
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Dosage:
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30 mg/kg, 100 mg/kg
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Administration:
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Subcutaneous injection; 30 minutes prior to Bz-ATP infusion
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Result:
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Significantly attenuated IL-1β release at 100 mg/kg, with no effect at 30 mg/kg dose group.
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N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101418 | JNJ-47965567 | | 1 mg | 400元 |
2024/08/19 | HY-101418 | N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE JNJ-47965567 | 1428327-31-4 | 5mg | 750元 |
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
生产厂家
1428327-31-4, N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE 相关搜索:
- 合成有机化合物配体
- JNJ 47965567,P2X7拮抗剂
- N-((4-(4-苯基哌嗪-1-基)四氢-2H-吡喃-4-基)甲基)-2-(苯硫基)烟酰胺
- 化合物JNJ-47965567
- 1428327-31-4
- Inhibitor,P2X7,JNJ-47965567,pain,JNJ 47965567,P2X Receptor,inhibit,neuropathic,JNJ47965567,P2XRs
- JNJ-47965567
- JNJ-47965567 >=98% (HPLC)
- 3-Pyridinecarboxamide, 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-
- 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
- JNJ-47965567
(JNJ47965567)
- N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
- JNJ-479655
- N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide