SYK INHIBITOR II
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- CAS号:
- 726695-51-8
- 英文名:
- Syk Inhibitor II
- 英文别名:
- 2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-;ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor
- 中文名:
- SYK INHIBITOR II
- 中文别名:
- 化合物SYK INHIBITOR II;2-((2-氨基乙基)氨基)-4-((3-三氟甲基)苯基)氨基)嘧啶-5-甲酰胺
- CBNumber:
- CB83152751
- 分子式:
- C14H15F3N6O
- 分子量:
- 340.3
- MOL File:
- 726695-51-8.mol
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SYK INHIBITOR II化学性质
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熔点:
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270-272 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
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沸点:
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541.6±60.0 °C(Predicted)
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密度:
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1.455±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 25 mg/ml; DMSO: 15 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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14.04±0.50(Predicted)
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颜色:
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White to off-white
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SYK INHIBITOR II性质、用途与生产工艺
Syk Inhibitor II 是一种有效的,高选择性和 ATP 竞争性 Syk 抑制剂,IC50 为 41 nM。Syk Inhibitor II 抑制 RBL 细胞释放 5-HT,IC50 为 460 nM。Syk Inhibitor II 对其他激酶的作用较小,并具有抗过敏作用。
serotonin
460 nM (IC
50
)
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Syk
41 nM (IC
50
)
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PKCε
5.1 μM (IC
50
)
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PKCβ2
11 μM (IC
50
)
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ZAP-70
11.2 μM (IC
50
)
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Btk
15.5 μM (IC
50
)
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Itk
22.6 μM (IC
50
)
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Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC
50
values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively.
Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID
50
value of 13.2 mg/kg.
SYK INHIBITOR II
上下游产品信息
上游原料
下游产品
726695-51-8, SYK INHIBITOR II 相关搜索:
- 2-((2-氨基乙基)氨基)-4-((3-三氟甲基)苯基)氨基)嘧啶-5-甲酰胺
- 化合物SYK INHIBITOR II
- 726695-51-8
- 2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide
- 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-
- ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor