THZ531
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- CAS号:
- 1702809-17-3
- 英文名:
- THZ-531
- 英文别名:
- THZ531;CPD1594;THZ-531;CS-2763;THZ531; THZ-531; THZ 531;THZ 531,inhibit,CDK,THZ-531,Cyclin dependent kinase,Inhibitor,THZ531;(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide;(S,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide;2-Butenamide, N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-, (2E)-
- 中文名:
- THZ531
- 中文别名:
- 化合物THZ531;THZ531游离态;(R,E)-N-(4-(3-((5-氯-4-(1H-吲哚-3-基)嘧啶-2-基)氨基)哌啶-1-羰基)苯基)-4- (二甲基氨基)丁-2-烯酰胺
- CBNumber:
- CB83153031
- 分子式:
- C30H32ClN7O2
- 分子量:
- 558.07
- MOL File:
- 1702809-17-3.mol
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THZ531化学性质
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密度:
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1.342±0.06 g/cm3(Predicted)
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溶解度:
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≥55.8 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH
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形态:
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solid
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酸度系数(pKa):
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13.12±0.70(Predicted)
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颜色:
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White to light yellow
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THZ531性质、用途与生产工艺
THZ531是CDK12和CDK13的选择性抑制剂，IC50值分别为158 nM和69 nM。
| Target | Value |
CDK13
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69 nM
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CDK12
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158 nM
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THZ531
上下游产品信息
上游原料
下游产品
1702809-17-3, THZ531 相关搜索:
- 抑制剂
- 药靶配体
- (R,E)-N-(4-(3-((5-氯-4-(1H-吲哚-3-基)嘧啶-2-基)氨基)哌啶-1-羰基)苯基)-4- (二甲基氨基)丁-2-烯酰胺
- 化合物THZ531
- THZ531游离态
- 1702809-17-3
- THZ 531,inhibit,CDK,THZ-531,Cyclin dependent kinase,Inhibitor,THZ531
- 2-Butenamide, N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-, (2E)-
- THZ531; THZ-531; THZ 531
- CS-2763
- (R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
- (S,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
- CPD1594
- THZ-531
- THZ531