ORG-26576; ORG26576; ORG 26576
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- CAS号:
- 1026791-61-6
- 英文名:
- Org-26576
- 英文别名:
- Org-26576;ORG26576; ORG 26576;ORG-26576; ORG26576; ORG 26576;(3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one;Org-26576,inhibit,Inhibitor,Org 26576,Ionotropic glutamate receptors,iGluR,Org26576
- 中文名:
- ORG-26576; ORG26576; ORG 26576
- 中文别名:
- 化合物ORG-26576
- CBNumber:
- CB83159442
- 分子式:
- C11H12N2O2
- 分子量:
- 204.22518
- MOL File:
- 1026791-61-6.mol
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ORG-26576; ORG26576; ORG 26576化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:20.0(Max Conc. mg/mL);97.9(Max Conc. mM)
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ORG-26576; ORG26576; ORG 26576性质、用途与生产工艺
Org-26576 是AMPA受体的正变构调节剂。
Org-26576 (Org 26576) represents structurally a distinct chemical series derived from the first generation ampakine CX516 and displays 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC
50
of 8-16 μM in rat hippocampal primary cultured neurons. Org-26576 demonstrates selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels and kinases.
Org-26576 (Org 26576; 1 mg/kg) produces significant increases in the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus and CA3 subfield of the hippocampus in mice. Chronic administration of Org-26576 (Org 26576) increases progenitor cell proliferation in dentate gyrus (approximately 40%) and in prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org-26576 in dentate gyrus exhibits increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype. AMPA receptor potentiation by Org-26576 (Org 26576) exerts a positive modulatory influence on brain derived neurotrophic factor (BDNF) expression during ongoing neuronal activity. Total BDNF mRNA levels are significantly increased in the hippocampus of animals exposed to the combination of Org-26576 and stress.
ORG-26576; ORG26576; ORG 26576
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101216 | ORG-26576; ORG26576; ORG 26576 Org-26576 | 1026791-61-6 | 5mg | 840元 |
2024/08/19 | HY-101216 | ORG-26576; ORG26576; ORG 26576 Org-26576 | 1026791-61-6 | 10mM * 1mLin DMSO | 920元 |
ORG-26576; ORG26576; ORG 26576
生产厂家
1026791-61-6, ORG-26576; ORG26576; ORG 26576 相关搜索:
- 化合物ORG-26576
- 1026791-61-6
- Org-26576,inhibit,Inhibitor,Org 26576,Ionotropic glutamate receptors,iGluR,Org26576
- ORG-26576; ORG26576; ORG 26576
- ORG26576; ORG 26576
- (3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one
- Org-26576