阿莫地喹
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- CAS号:
- 86-42-0
- 英文名:
- Amodiaquine
- 英文别名:
- CAM-AQI;CAM-AQ1;Miaquin;Camoquin;Camochin;Camoquine;SN 10,751;NSC 13453;Camoquinal;Flavoquine
- 中文名:
- 阿莫地喹
- 中文别名:
- 氨酚喹;氨酚喹啉;阿莫地喹;阿莫地喹杂质;阿莫地喹 -D10;4-((7-氯喹啉-4-基)氨基)-2-((二乙基氨基)甲基)苯酚
- CBNumber:
- CB8344720
- 分子式:
- C20H22ClN3O
- 分子量:
- 355.86
- MOL File:
- 86-42-0.mol
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阿莫地喹化学性质
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熔点:
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208°C
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沸点:
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478.0±45.0 °C(Predicted)
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密度:
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1.258
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly, Sonicated), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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9.43±0.50(Predicted)
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颜色:
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Pale Yellow to Light Yellow
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CAS 数据库:
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86-42-0(CAS DataBase Reference)
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NIST化学物质信息:
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Amodiaquine(86-42-0)
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阿莫地喹性质、用途与生产工艺
阿莫地喹用于治疗各种疟疾，尤其是治疗对其他抗疟药(如氯喹)产生耐药的恶性疟原虫引起的疟疾，也用于疟疾的急性发作，具有良好的耐受性。
本品还可用于治疗肝阿米巴病、华支睾吸虫病、肺吸虫病、结缔组织病等，另可用于治疗光敏性疾患，如日晒红斑症。
阿莫地喹为氨基喹啉类抗疟药，是一种有效的裂殖体杀灭剂。其抗疟作用与氯喹相似，作用于红内期疟原虫，能迅速控制临床症状。本品对于抗氯喹的疟原虫也有效。
口服卫生部推荐的治疗恶性疟方案：每日顿服青蒿琥酯片200mg和阿莫地喹片600mg，连服3日。预防用每周顿服2片。治疗用首日顿服3片，第2、3日各顿服2片。
Amodiaquine是一种合成的氨基喹啉，通过与原生动物或寄生DNA结合、阻止DNA和RNA的生成以及后续蛋白质的合成。它被用于治疗疟疾。
EC50: ~20 μM (Nurr1-LBD (ligand binding domain))
Histamine N-methyltransferase
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
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neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
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Cell Line:
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Primary microglia
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Concentration:
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10 µM, 15 µM, 20 µM
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Incubation Time:
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4 hours
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Result:
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Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
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Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
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Animal Model:
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Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH)
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Dosage:
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40 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 3 days
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Result:
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Diminished perihematomal activation of microglia/macrophages and astrocytes.
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用途
用作抗疟药
阿莫地喹
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-B1322A | Amodiaquine | | 5 mg | 1200元 |
| 2024/11/08 | HY-B1322A | Amodiaquine | | 10 mg | 1900元 |
阿莫地喹
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86-42-0, 阿莫地喹 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Amines
- 抑制剂
- 抗疟配体
- 化合物
- 医药原料药
- C20H22ClN3O
- C20H12ClN3OD10
- 4-((7-氯喹啉-4-基)氨基)-2-((二乙基氨基)甲基)苯酚
- 阿莫地喹杂质
- 阿莫地喹 -D10
- 氨酚喹啉
- 阿莫地喹
- 氨酚喹
- 86-42-0
- AMODIQUINE BASE
- Amodiaquine 150-200 mg Tablet
- AmodiaquineQ: What is
Amodiaquine Q: What is the CAS Number of
Amodiaquine Q: What is the storage condition of
Amodiaquine Q: What are the applications of
Amodiaquine
- Amodiaquine USP/EP/BP
- NSC 13453
- DRUGS: AMODIAQUINE USP
- 4-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol
- 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
- 4-[(7-Chloro-4-quinolynyl)amino]-2-[(diethylamino)methyl]phenol
- Amodiaquine (base and/or unspecified salts)
- 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol, SN-10751
- 4-[7-Chloro-4-quinolylamino]-α-diethylamino-o-cresol
- 4-[3'-Dimethyl-aminomethyl-4'-hydroxyanilino]-7-chloroquinoline
- Amodiaquine USP24
- 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol
- AMODIAQUINE
- AMODIAQUIN
- 7-chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline
- SN 10,751
- S. N. 10751
- Quinoline, 7-chloro-4-((3-((diethylamino)methyl)-4-hydroxyphenyl)amino)-
- Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
- o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-
- Miaquin
- Flavoquine
- Camoquine
- Camoquinal
- Camoquin
- Camochin
- CAM-AQI
- CAM-AQ1
- Amodiaquine, ring-closed
- 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline
- 4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol
- 4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol
- 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso