PD 144418草酸盐
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- CAS号:
- 1794760-28-3
- 英文名:
- IWSFHSVGBKPYFN-UHFFFAOYSA-N
- 英文别名:
- IWSFHSVGBKPYFN-UHFFFAOYSA-N
- 中文名:
- PD 144418草酸盐
- 中文别名:
- PD 144418草酸盐
- CBNumber:
- CB83574883
- 分子式:
- C20H24N2O5
- 分子量:
- 372.42
- MOL File:
- 1794760-28-3.mol
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PD 144418草酸盐化学性质
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溶解度:
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Soluble to 50 mM in DMSO
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形态:
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Solid
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颜色:
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White to off-white
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PD 144418草酸盐性质、用途与生产工艺
PD 144418 oxalate 是一种高亲和力，强效和选择性的 sigma 1 受体 (σ1 receptor) 配体 (对 σ1 和 σ2 的 Ki 值分别为 0.08 nM 和 1377 nM)，对其他受体，离子通道和酶没有任何显着的亲和力。PD 144418 oxalate 具有潜在的抗精神病活性。
Ki: 0.08 nM (σ1 receptor) and 1377 nM (σ2 receptor)
In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis.
PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED
50
values of 7.0 mg/kg i.p..
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Animal Model:
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Male CD-1 mice induced with Mescaline
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Dosage:
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10 mg/kg
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Administration:
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Intraperitoneal injection; once
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Result:
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Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.
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PD 144418草酸盐
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1794760-28-3, PD 144418草酸盐 相关搜索:
- 抑制剂
- 药靶配体
- PD 144418草酸盐
- 1794760-28-3
- IWSFHSVGBKPYFN-UHFFFAOYSA-N