网站主页 >> CAS数据库列表 >> N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
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- CAS号:
- 210345-00-9
- 英文名:
- CASPASE-1 INHIBITOR TFA SALT
- 英文别名:
- Z-WEHD-FMK-TFA;CASPASE-1 INHIBITOR TFA SALT;Caspase-1/ICE Inhibitor Z-WEHD-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA;Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE;N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester;L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI)
- 中文名:
- N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
- 中文别名:
- N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
- CBNumber:
- CB8382359
- 分子式:
- C37H42FN7O10
- 分子量:
- 763.77
- MOL File:
- 210345-00-9.mol
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N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯化学性质
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沸点:
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1129.2±65.0 °C(Predicted)
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密度:
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1.349±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥26.32 mg/mL in EtOH with ultrasonic; ≥46.33 mg/mL in DMSO
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形态:
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Powder
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酸度系数(pKa):
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11.06±0.46(Predicted)
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颜色:
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Light yellow to yellow
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N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯性质、用途与生产工艺
Z-WEHD-FMK 是一种强效具有细胞通透性可逆的 caspase-1/5 抑制剂。Z-WEHD-FMK 也抑制 cathepsin B 的活性 (IC50=6 μM)。Z-WEHD-FMK 可用于检测细胞凋亡。
Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of
C. trachomatis
-induced cleavage of golgin-84 and increases GM130 expression in cells.Z-WEHD-FMK (30 min before being exposed to
E. piscicida
) effectively inhibits 0909I
E. piscicida
induced ZF4 cells cytotoxicity and pyroptotic morphology. And in addition, it also inhibits the cytotoxicity induced by cytosolic LPS delivery.Z-WEHD-FMK (20 μM;18-24 hours following Cr
3+
,Ni
2+
, and Co
2+
) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr
3+
, it also induces a decrease of 35% to 45% with 48 ppm Ni
2+
or higher, Finally, this caspase-1 inhibitor induced a decrease with 6 ppm Co
2+
, down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co
2+
in bone marrow-derived macrophages (BMDM).
Western Blot Analysis
Cell Line:
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C. trachomatis
- or mock-infected HeLa cells
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Concentration:
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80 μM
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Incubation Time:
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9 hours
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Result:
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Increased golgin-84 and GM130 expression.
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Cell Viability Assay
Cell Line:
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Mycoplasma free-ZF4 cells
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Concentration:
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Incubation Time:
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30 min before being exposed to
E. piscicida
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Result:
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Inhibited ZF4 cells cytotoxicity and pyroptotic morphology.
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N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
上下游产品信息
上游原料
下游产品
N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
生产厂家
210345-00-9, N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯 相关搜索:
- Apoptosis
- 多肽
- C37H42FN7O10
- N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
- 210345-00-9
- L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI)
- Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
- Caspase-1/ICE Inhibitor Z-WEHD-FMK
- N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester
- Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA
- Z-WEHD-FMK-TFA
- CASPASE-1 INHIBITOR TFA SALT