374703-78-3
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- CAS号:
- 374703-78-3
- 英文名:
- PKG drug G1
- 英文别名:
- PKG drug G1;PKG drug G 1,PKG drug G-1,PKG drug G1,Inhibitor,inhibit;5-((2-Methyl-1H-indol-3-yl)methylene)-2-thioxoimidazolidin-4-one;4-Imidazolidinone, 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-
- 中文名:
- 374703-78-3
- 中文别名:
- 化合物PKG DRUG G1;5-((2-甲基-1H-吲哚-3-基)亚甲基)-2-硫代咪唑啉-4-酮
- CBNumber:
- CB84656562
- 分子式:
- C13H11N3OS
- 分子量:
- 257.31
- MOL File:
- 374703-78-3.mol
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374703-78-3化学性质
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密度:
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1.45±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): Partially soluble
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形态:
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A crystalline solid
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酸度系数(pKa):
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6.71±0.20(Predicted)
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颜色:
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Light brown to reddish brown
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374703-78-3性质、用途与生产工艺
PKG drug G1 是靶向C42的 Protein Kinase G Iα (PKG Iα) 的激活剂,可导致血管舒张和血压下降。
PKG drug G1 induces vasodilation of isolated resistance blood vessels and blood pressure lowering in a mouse model of angiotensin II–induced hypertension. PKG drug G1 efficiently relaxes WT but not knockin (KI) vessels, which is then assessed in a murine model of hypertension. PKG drug G1 lowers blood pressure in hypertensive WT, but not KI, mice in vivo. PKG drug G1 is tested in vivo in healthy mice implanted with telemetric devices that allow blood pressure and heart rate to be constantly monitored. PKG drug G1 or vehicle control is administrated by intraperitoneal injection, and the acute impact on hemodynamics assessed. PKG drug G1 administered at 7.4 mg/kg does not decrease blood pressure, but there is a concomitant reflex tachycardia. When this is repeated using 14.8 mg/kg dose of PKG drug G1, again blood pressure is not altered-but this higher dose induces a potentiated increase in heart rate.
374703-78-3
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上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-112197 | 374703-78-3 PKG drug G1 | 374703-78-3 | 5mg | 729元 |
2024/08/19 | HY-112197 | 374703-78-3 PKG drug G1 | 374703-78-3 | 10mM * 1mLin DMSO | 801元 |
374703-78-3, 374703-78-3 相关搜索:
- 抑制剂
- 药靶配体
- 5-((2-甲基-1H-吲哚-3-基)亚甲基)-2-硫代咪唑啉-4-酮
- 化合物PKG DRUG G1
- 374703-78-3
- 5-((2-Methyl-1H-indol-3-yl)methylene)-2-thioxoimidazolidin-4-one
- PKG drug G 1,PKG drug G-1,PKG drug G1,Inhibitor,inhibit
- 4-Imidazolidinone, 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-
- PKG drug G1