ML-9盐酸盐
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- CAS号:
- 105637-50-1
- 英文名:
- ML-9 HYDROCHLORIDE
- 英文别名:
- ML-9;ML-9, HCl;ML 9 HCl salt;ML-9 HYDROCHLORIDE;1-(5-CHLORONAPHTHALENE- SULFONYL)HOMOPIPERAZINE;1-(5-chloronaphthalene-1-sulfonyl)-1H-*hexahydro-;ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem;1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HE XAHYDRO-1,;1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL;1-(chloronaphthalenesulfonyl)-1H-hexahydrodiazepine HCl
- 中文名:
- ML-9盐酸盐
- 中文别名:
- ML-9盐酸盐;ML-9,蛋白激酶抑制剂;1-(5-氯萘磺酰基)-1H-六氢-1,4-二氮杂卓, 盐酸盐;1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐;1-(5-氯萘-1-磺酰基)-1H-六氢-1,4-二吖庚因盐酸盐
- CBNumber:
- CB8477299
- 分子式:
- C15H18Cl2N2O2S
- 分子量:
- 361.28
- MOL File:
- 105637-50-1.mol
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ML-9盐酸盐化学性质
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熔点:
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196-200
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储存条件:
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2-8°C
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溶解度:
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ethanol: 10 mg/mL
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形态:
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powder
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颜色:
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white
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ML-9盐酸盐性质、用途与生产工艺
ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。
| Target | Value |
Akt
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MLCK
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STIM1
()
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Ca2+-permeable channels
()
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ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death.
ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
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Cell Line:
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Neonatal rat ventricular myocytes (NRVM) cells
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Concentration:
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0, 10, 50 and 100 μM
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Incubation Time:
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0, 1, 4, 8 and 24 hours
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Result:
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Decreased cell viability at 50-100 μM concentration.
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Apoptosis Analysis
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Cell Line:
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Neonatal rat ventricular myocytes (NRVM) cells
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Concentration:
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50 μM
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Incubation Time:
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1, 4 and 8 hours
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Result:
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Induced cardiomyocyte death through necrosis and apoptosis.
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ML-9盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-100932 | ML-9 | | 5 mg | 440元 |
| 2024/08/19 | HY-100932 | ML-9盐酸盐
ML-9 | 105637-50-1 | 10mM * 1mLin DMSO | 484元 |
ML-9盐酸盐
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ML-9盐酸盐国内生产厂家
105637-50-1, ML-9盐酸盐 相关搜索:
- Protein Kinase Inhibitors and Activators
- 抑制剂
- 药靶配体
- 生化试剂
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Serine/Threonine Kinase Inhibitors
- Myosin Light Chain Kinase (MLCK)
- Kinase/Phosphatase Biology
- C15H17ClN2O2SHCl
- C15H17ClN2O2SClH
- C15H17N2O2SClHCl
- C15H18Cl2N2O2S
- ML-9,蛋白激酶抑制剂
- 1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐
- ML-9盐酸盐
- 1-(5-氯萘-1-磺酰基)-1H-六氢-1,4-二吖庚因盐酸盐
- 1-(5-氯萘磺酰基)-1H-六氢-1,4-二氮杂卓, 盐酸盐
- 105637-50-1
- viability,STIM1,Inhibitor,MLCK,caspase,ML 9,Myosin,ML9,inhibit,ML-9,cardiomyocyte
- ML 9 HCl salt
- ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem
- 1-[(5-chloro-1-naphthalenyl)sulfonyl]-1,4-diazepan-4-ium
- 1-(5-CHLORONAPHTHALENE- SULFONYL)HOMOPIPERAZINE
- 1-[(5-chloro-1-naphthyl)sulfonyl]-1,4-diazepane hydrochloride
- 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride
- 1-(chloronaphthalenesulfonyl)-1H-hexahydrodiazepine HCl
- 1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE
- 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, hydrochloride (1:1)
- 1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HE XAHYDRO-1,
- ML-9, HCl
- 1-(5-chloronaphthalene-1-sulfonyl)-1H-*hexahydro-
- 1-(5-CHLORONAPHTHALENESULPHONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE
- 1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
- 1-(5-CHLORONAPHTHALENESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, HYDROCHLORIDE
- 1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL
- 1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE
- 1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL
- ML-9 HYDROCHLORIDE
- ML-9