GT 949
|
|
|
- CAS号:
- 460330-27-2
- 英文名:
- GT 949
- 英文别名:
- GT 949;3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
- 中文名:
- GT 949
- 中文别名:
- 化合物GT 949;化合物 T15446;GT 949,EAAT2的正变构调节剂
- CBNumber:
- CB84844846
- 分子式:
- C30H37N7O2
- 分子量:
- 527.66
- MOL File:
- 460330-27-2.mol
|
|
|
GT 949化学性质
-
沸点:
-
770.7±60.0 °C(Predicted)
-
|
-
密度:
-
1.32±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 100 mM; Ethanol: 10 mM, heated
-
|
-
形态:
-
A solid
-
|
-
酸度系数(pKa):
-
10.55±0.70(Predicted)
-
|
-
颜色:
-
Off-white to light yellow
-
|
GT 949性质、用途与生产工艺
GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂，EC50 为 0.26 nM。
EC50: 0.26±0.03 nM (EAAT2)
GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in V
max
of about 47%.
GT 949
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-114381 | GT 949
GT 949 | 460330-27-2 | 5mg | 800元 |
| 2024/04/30 | HY-114381 | GT 949
GT 949 | 460330-27-2 | 10mg | 1400元 |
460330-27-2, GT 949 相关搜索:
- 药靶配体
- GT 949,EAAT2的正变构调节剂
- 化合物GT 949
- 化合物 T15446
- 460330-27-2
- 2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
- 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
- GT 949