2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
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- CAS号:
- 1049741-55-0
- 英文名:
- 4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
- 英文别名:
- CARDIOGENOL C HYDROCHLORIDE;Cardiogenol C hydrochloride(b);2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride;4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE;2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1);Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)
- 中文名:
- 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
- 中文别名:
- 心源醇C 盐酸盐;2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
- CBNumber:
- CB8668084
- 分子式:
- C13H17ClN4O2
- 分子量:
- 296.75
- MOL File:
- Mol file
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐化学性质
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储存条件:
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−20°C
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溶解度:
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H2O: 10 mg/mL, soluble
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形态:
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solid
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颜色:
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White to off-white
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐性质、用途与生产工艺
Cardiogenol C hydrochloride 是一种有效的细胞渗透性嘧啶诱导剂,可促使 ESCs 分化为心肌细胞 (ESCs differentiation into cardiomyocytes) (EC50=100 nM)。Cardiogenol C hydrochloride 还可以在有限的可塑性范围内对已经沿袭的祖细胞类型产生心肌生成效应。Cardiogenol C hydrochloride 是一种有用的心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。
EC50: 100 nM (differentiation of ESCs into cardiomyocytes)
Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,
nppa
) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.
RT-PCR
Cell Line:
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C2C12 cells
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Concentration:
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0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM
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Incubation Time:
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7 days
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Result:
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Increased
ANF
and
NKX2.5
mRNA level as a dose-dependent manner.
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Western Blot Analysis
Cell Line:
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C2C12 cells
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Concentration:
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0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
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Incubation Time:
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7 days
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Result:
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Increased cardiac Nav1.5 sodium channel protein levels.
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Cell Proliferation Assay
Cell Line:
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C2C12 cells
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Concentration:
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0.01 μM; 0.1 μM; 1 μM
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Incubation Time:
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7 days
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Result:
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Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 Cardiogenol C hydrochloride | 1049741-55-0 | 5mg | 700元 |
2024/01/25 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 Cardiogenol C hydrochloride | 1049741-55-0 | 10mM * 1mLin DMSO | 770元 |
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
生产厂家
1049741-55-0, 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 相关搜索:
- Agro Products
- Aromatics
- Agonist
- 药靶配体
- C12H15ClN4O2
- 心源醇C 盐酸盐
- 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
- 1049741-55-0
- Cardiogenol C hydrochloride(b)
- Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)
- 2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1)
- 2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride
- 4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
- CARDIOGENOL C HYDROCHLORIDE