豚鼠髓磷脂碱性蛋白片段68-82
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- CAS号:
- 98474-59-0
- 英文名:
- TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
- 英文别名:
- des-Gly77;MYELIN BASIC PROTEIN, FRAGMENT 68-82;MYELIN BASIC PROTEIN (68-82), GUINEA PIG;(Des-Gly77,Des-His78)-MBP (68-84) (bovine);MYELIN BASIC PROTEIN MBP (68-82), GUINEA PIG;MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG;myelin basic protein guinea pig fragment 68-82;(Des-Gly77,Des-His78)-MBP (68-84) (guinea pig);MBP (68-82),Myelin Basic Protein (68-84), guinea pig;DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64
- 中文名:
- 豚鼠髓磷脂碱性蛋白片段68-82
- 中文别名:
- 髓鞘碱性蛋白豚鼠片段 68-82;豚鼠髓磷脂碱性蛋白片段68-82;MYELIN BASIC PROTEIN (68-82), GUINEA PIG ;(DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (GUINEA PIG);L-酪氨酰甘氨酰-L-丝氨酰-L-亮氨酰-L-脯氨酰-L-谷氨酰胺酰-L-赖氨酰-L-丝氨酰-L-谷氨酰胺酰-L-精氨酰-L-丝氨酰-L-谷氨酰胺酰-L-ALPHA-天冬氨酰-L-ALPHA-谷氨酰-L-天冬氨酰胺
- CBNumber:
- CB8721158
- 分子式:
- C71H113N23O28
- 分子量:
- 1736.81
- MOL File:
- 98474-59-0.mol
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豚鼠髓磷脂碱性蛋白片段68-82化学性质
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储存条件:
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-20°C
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溶解度:
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insoluble in EtOH; ≥173.6 mg/mL in DMSO; ≥54.6 mg/mL in H2O
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形态:
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solid
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颜色:
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White to off-white
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序列:
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H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH
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豚鼠髓磷脂碱性蛋白片段68-82性质、用途与生产工艺
髓磷脂碱性蛋白(myelinbasicprotein，MBP)是髓鞘的主要成分，是诱导实验性自身免疫性脑脊髓炎(experimentalautoimmuneencephalomyelitis，EAE)的重要抗原。EAE的病理学特征是：CNS血管周围大量单个核细胞浸润并造成炎性损伤，用MBP加佐剂主动免疫敏感动物或过继转移MBP特异性CD4+T细胞都可引发EAE。然而，将MBP致敏的T淋巴细胞直接注入实验动物的CNS不能诱发EAE，但将同样数量MBP致敏的T淋巴细胞由皮下或外周注射均可引起EAE，提示在外周针对MBP的淋巴细胞活化和活化后穿过血脑屏障是致病的重要因素。豚鼠髓磷脂碱性蛋白片段68-82是髓鞘碱性蛋白(MBP)的一个片段，结构为tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn
Myelin Basic Protein (MBP) (68-82), guinea pig 是髓鞘碱性蛋白 (MBP) 的一个片段。
Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples are analyzed for activation capacity and the activatability of CD4
+
and CD8
+
T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4
+
and CD8
+
T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82)).
Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP + BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP + BVA group as compared to rats in the MBP group.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
豚鼠髓磷脂碱性蛋白片段68-82
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P1048 | 豚鼠髓磷脂碱性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig | 98474-59-0 | 1mg | 700元 |
| 2024/04/30 | HY-P1048 | 豚鼠髓磷脂碱性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig | 98474-59-0 | 5mg | 1500元 |
98474-59-0, 豚鼠髓磷脂碱性蛋白片段68-82 相关搜索:
- Neuroscience
- Peptide
- 目录肽
- 多肽
- 标准品
- 细胞生物学
- Amino Acids and Peptides
- BioChemical
- Biochemicals and Reagents
- Miscellaneous Neuropeptides
- Other Neuropeptides
- Peptides
- C73H115N23O26
- MYELIN BASIC PROTEIN (68-82), GUINEA PIG ;(DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (GUINEA PIG)
- 髓鞘碱性蛋白豚鼠片段 68-82
- 豚鼠髓磷脂碱性蛋白片段68-82
- L-酪氨酰甘氨酰-L-丝氨酰-L-亮氨酰-L-脯氨酰-L-谷氨酰胺酰-L-赖氨酰-L-丝氨酰-L-谷氨酰胺酰-L-精氨酰-L-丝氨酰-L-谷氨酰胺酰-L-ALPHA-天冬氨酰-L-ALPHA-谷氨酰-L-天冬氨酰胺
- 98474-59-0
- MBP (68-82),Myelin Basic Protein (68-84), guinea pig
- Myelin Basic Protein (MBP) (68-82), guinea pig,Inhibitor,inhibit,Myelin Basic Protein (MBP) (68 82), guinea pig,Myelin Basic Protein (MBP) (6882), guinea pig
- TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN USP/EP/BP
- (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig) H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH
- Myelin basic protein guinea pig fragment 68-82, ≥97% (HPLC)
- DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64
- DES-[GLY77,HIS78] MYELIN BASIC PROTEIN (68-84), BOVINE
- DES-GLY77, DES-HIS78-MYELIN BASIC PROTEIN FRAGMENT 68-84 BOVINE
- (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (GUINEA PIG)
- (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (BOVINE)
- H-TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN-OH
- H-TYR-GLY-SER-LEU-PRO-GLN-LYS-ALA-GLN-ARG-PRO-GLN-ASP-GLU-ASN-OH
- L-Tyrosylglycyl-L-seryl-L-leucyl-L-prolyl-L-glutaminyl-L-lysyl-L-seryl-L-glutaminyl-L-arginyl-L-seryl-L-glutaminyl-L-alpha-aspartyl-L-alpha-glutamyl-L-asparagine
- (Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)
- (Des-Gly77,Des-His78)-MBP (68-84) (bovine)
- (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig)
(Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)
- des-His78-Myelin Basic Protein Bovine fragment 68-84
- des-Gly77
- myelin, basic protein, fragment 68-84, des-Gly77, his78
- MYELIN BASIC PROTEIN MBP (68-82), GUINEA PIG
- DES-GLY77, HIS78-MYELIN BASIC PROTEIN FRAGMENT 68-84 BOVINE
- myelin basic protein guinea pig fragment 68-82
- des-gly77, des-his78-myelin basic protein bovine fragment 68-84
- MYELIN BASIC PROTEIN (68-82), GUINEA PIG
- MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG
- MYELIN BASIC PROTEIN, FRAGMENT 68-82
- TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
- TYR-GLY-SER-LEU-PRO-GLN-LYS-ALA-GLN-ARG-PRO-GLN-ASP-GLU-ASN
- TYR-GLY-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
- DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84