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MIDAGLIZOLE HYDROCHLORIDE

生物活性 靶点 体外研究 体内研究 MIDAGLIZOLE HYDROCHLORIDE 试剂级价格
MIDAGLIZOLE HYDROCHLORIDE, 79689-25-1, 结构式
MIDAGLIZOLE HYDROCHLORIDE
CAS号:
79689-25-1
英文名:
2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride
英文别名:
Midaglizole hydrochloride;2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride;Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
中文名:
MIDAGLIZOLE HYDROCHLORIDE
中文别名:
咪格列唑盐酸盐;化合物 T11015
CBNumber:
CB91256447
分子式:
C16H19Cl2N3
分子量:
0
MOL File:
79689-25-1.mol

MIDAGLIZOLE HYDROCHLORIDE化学性质

储存条件:
Store at -20°C
溶解度:
Soluble in DMSO
形态:
Solid
颜色:
White to off-white
安全信息

MIDAGLIZOLE HYDROCHLORIDE性质、用途与生产工艺

生物活性

Midaglizole hydrochloride (DG5128) 是有效的 α2-肾上腺素受体拮抗剂。Midaglizole hydrochloride (DG5128) 对 α2-肾上腺素能受体的亲和力 (pKi= 6.28) 比 α1-肾上腺素能受体高 7.4 倍。

靶点

pKi :6.28 (α2-adrenoceptor)

体外研究

Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [ 3 H]clonidine binding more effectively than it doed [ 3 H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action. The EC 50 values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC 50 values for K ATP current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively.

体内研究

Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats.

MIDAGLIZOLE HYDROCHLORIDE 上下游产品信息

上游原料

下游产品

MIDAGLIZOLE HYDROCHLORIDE 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-U00165Midaglizole hydrochloride1 mg1760元
2024/04/30HY-U00165MIDAGLIZOLE HYDROCHLORIDE
Midaglizole hydrochloride		5 mg4400元

MIDAGLIZOLE HYDROCHLORIDE 生产厂家

全球有 8家供应商   MIDAGLIZOLE HYDROCHLORIDE国内生产厂家
供应商联系电话电子邮件国家产品数优势度
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn 美国 4863 58
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
成都超九八生物科技有限公司 13348960310 13348960310 3003867561@qq.com 中国 10000 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29778 58
TargetMol中国（陶术生物） 4008200310 marketing@tsbiochem.com 中国 23963 58
 

79689-25-1, MIDAGLIZOLE HYDROCHLORIDE 相关搜索:

  • C16H19Cl2N3
  • 化合物 T11015
  • 咪格列唑盐酸盐
  • 79689-25-1
  • Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
  • Midaglizole hydrochloride
  • 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride
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