MIDAGLIZOLE HYDROCHLORIDE
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- CAS号:
- 79689-25-1
- 英文名:
- 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride
- 英文别名:
- Midaglizole hydrochloride;2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride;Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
- 中文名:
- MIDAGLIZOLE HYDROCHLORIDE
- 中文别名:
- 咪格列唑盐酸盐;化合物 T11015
- CBNumber:
- CB91256447
- 分子式:
- C16H19Cl2N3
- 分子量:
- 0
- MOL File:
- 79689-25-1.mol
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MIDAGLIZOLE HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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White to off-white
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MIDAGLIZOLE HYDROCHLORIDE性质、用途与生产工艺
Midaglizole hydrochloride (DG5128) 是有效的 α2-肾上腺素受体拮抗剂。Midaglizole hydrochloride (DG5128) 对 α2-肾上腺素能受体的亲和力 (pKi= 6.28) 比 α1-肾上腺素能受体高 7.4 倍。
pKi :6.28 (α2-adrenoceptor)
Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [
3
H]clonidine binding more effectively than it doed [
3
H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action. The EC
50
values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC
50
values for K
ATP
current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively.
Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats.
MIDAGLIZOLE HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00165 | Midaglizole hydrochloride | | 1 mg | 1760元 |
2024/04/30 | HY-U00165 | MIDAGLIZOLE HYDROCHLORIDE Midaglizole hydrochloride | | 5 mg | 4400元 |
MIDAGLIZOLE HYDROCHLORIDE
生产厂家
79689-25-1, MIDAGLIZOLE HYDROCHLORIDE 相关搜索:
- C16H19Cl2N3
- 化合物 T11015
- 咪格列唑盐酸盐
- 79689-25-1
- Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
- Midaglizole hydrochloride
- 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride