Ki: 0.4 nM (hCRF 1 , cell assay), 0.3 nM (rCRF 2α , cell assay), and 0.5 nM (mCRF 2β , cell assay)
Urocortin, human is a selective agonist of CRF 2 receptor, with K i s of 0.4, 0.3, and 0.5 nM for human CRF 1 , rat CRF 2α and mouse CRF 2β receptors in cell assay, respectively.
Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior.