Hygrolidin
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- CAS号:
- 83329-73-1
- 英文名:
- Hygrolidin
- 英文别名:
- 1166C;Hygrolidin;Antibiotic 1166C;2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
- 中文名:
- Hygrolidin
- 中文别名:
- 潮内酯
- CBNumber:
- CB92219966
- 分子式:
- C38H58O11
- 分子量:
- 690.86
- MOL File:
- 83329-73-1.mol
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Hygrolidin化学性质
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沸点:
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821.1±65.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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A solid
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酸度系数(pKa):
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3.28±0.10(Predicted)
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Hygrolidin性质、用途与生产工艺
Hygrolidin 是一种 16 元大环内酯类抗生素，来自于吸水链霉菌 (Streptomyces hygroscopicus) D-1166。Hygrolidin 对 Valsa ceratosperma 具有抗真菌活性。Hygrolidin 诱导 p21 表达并中止 G1 和 S 期的细胞周期进程。Hygrolidin 具有抗肿瘤活性。
Hygrolidin (0.1, 1 μg/ml; for 24 h) increases both G1 and S phase populations and decreases M phase population.
Hygrolidin (0.1, 1, 10 μg/ml; for 24 h) decreases the amounts of cdk4, cyclin D, cyclin B and increases the amounts of cyclin E and p21. Hygrolidin-induced p21 preferentially associates with cyclin A-cdk2 complex and inhibits it.
Hygrolidin (0.1, 1 μg/ml; for 24 h) selectively induces p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
Hygrolidin, for 3 days, inhibits growth of various cell lines including DLD-1 colon cancer, LNCaP prostate cancer, K562 leukemia cells, LNCaP prostate cancer, EL-4 lymphoma (IC
50
s = 1.0-33 ng/ml, respectively).
Hygrolidin shows growth inhibition on
Trypanosoma cruzi
(IC
50
=1.1 nM),
Trypanosoma brucei brucei
(IC
50
=77 nM), and
Leishmania donovani
(IC
50
=72.5 nM).
Cell Cycle Analysis
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Cell Line:
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DLD-1 cells
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Concentration:
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0.1, 1 μg/ml
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Incubation Time:
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For 24 hours
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Result:
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Increased both G1 and S phase populations and decreased M phase population.
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Western Blot Analysis
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Cell Line:
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DLD-1 cells
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Concentration:
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0.1, 1, 10 μg/ml
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Incubation Time:
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For 24 hours
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Result:
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Decreased the amounts of cdk4, cyclin D, cyclin B and increased the amounts of cyclin E and p21.
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RT-PCR
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Cell Line:
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DLD-1 or WI-38 cells
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Concentration:
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0.1, 1 μg/ml
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Incubation Time:
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For 24 hours
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Result:
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Selectively induced p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
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Hygrolidin
上下游产品信息
上游原料
下游产品
83329-73-1, Hygrolidin 相关搜索:
- Antibiotic
- 微生物代谢物
- 潮内酯
- 83329-73-1
- 2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
- Hygrolidin
- Antibiotic 1166C
- 1166C