L-689,560
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- CAS号:
- 139051-78-8
- 英文名:
- L-689,560
- 英文别名:
- L-689,560;TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE;4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline;2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-, (2R,4S)-rel-
- 中文名:
- L-689,560
- 中文别名:
- 化合物 T15684;化合物 L-689560;L-689,560,NMDA拮抗剂
- CBNumber:
- CB9236350
- 分子式:
- C17H15Cl2N3O3
- 分子量:
- 380.23
- MOL File:
- 139051-78-8.mol
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L-689,560化学性质
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熔点:
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172-173°C
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沸点:
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549.1±50.0 °C(Predicted)
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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<9.51mg/ml in DMSO; <38.02mg/ml in ethanol
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形态:
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solid
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酸度系数(pKa):
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11.16±0.20(Predicted)
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颜色:
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White
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L-689,560性质、用途与生产工艺
L-689560 是一种有效的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂，抑制 GluN1 甘氨酸结合位点。L-689560 在广泛用作结合研究中的放射性标记配体，也用来研究 NMDA 受体在正常神经系统过程以及疾病中的作用。
L-689560 is a 2-carboxytetrahydroquinoline antagonist.
L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model
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Animal Model:
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Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model
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Dosage:
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1 mg/kg
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Administration:
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IP
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Result:
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Significantly reduced the neuroprotective effect of glycine after glycine receptors.
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L-689,560
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101178 | L-689560 | | 1 mg | 1450元 |
| 2024/11/08 | HY-101178 | L-689,560
L-689560 | 139051-78-8 | 5mg | 3800元 |
139051-78-8, L-689,560 相关搜索:
- 抑制剂
- C17H15N3O3Cl2
- 化合物 L-689560
- L-689,560,NMDA拮抗剂
- 化合物 T15684
- 139051-78-8
- 2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-, (2R,4S)-rel-
- 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
- TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE
- L-689,560