226226-39-7
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- CAS号:
- 226226-39-7
- 英文名:
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride
- 英文别名:
- Teijin compound 1;CCR2 antagonist 4;Teijin compound 1 hydrochloride;N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxo-ethyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-;N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride;CCR-2 antagonist 4,CCR2b,CCR,chemokines,chemotaxis,Inhibitor,inhibit,inflammatory,MCP-1,chronic,CCR2 antagonist 4,CC chemokine receptor,Teijin compound1,Teijin compound-1
- 中文名:
- 226226-39-7
- 中文别名:
- 化合物 T13114;CCR2 ANTAGONIST 4;化合物CCR2 ANTAGONIST 4
- CBNumber:
- CB92518850
- 分子式:
- C21H21ClF3N3O2
- 分子量:
- 439.86
- MOL File:
- 226226-39-7.mol
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226226-39-7化学性质
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沸点:
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597.9±50.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Desiccate at +4°C
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溶解度:
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DMSO: ≥20mg/mL
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酸度系数(pKa):
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12.94±0.46(Predicted)
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形态:
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powder
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颜色:
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white to tan
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226226-39-7性质、用途与生产工艺
CCR2 antagonist 4 (Teijin compound 1) 是一种高效、特异的 CCR2 拮抗剂,对 CCR2b 的 IC50 值为 180 nM。CCR2 antagonist 4 对 MCP-1 诱导的趋化作用有较强的抑制作用,其 IC50 为 24 nM。
Ile263 and Thr292 in CCR2 contribute significantly to binding of Teijin compound 1 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4.
In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.
226226-39-7
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-108323 | CCR2 antagonist 4 | | 1 mg | 600元 |
2024/04/30 | HY-108323 | 226226-39-7 CCR2 antagonist 4 | 226226-39-7 | 10mM * 1mLin DMSO | 1650元 |
226226-39-7, 226226-39-7 相关搜索:
- C21H21CIF3O2HCl
- 化合物CCR2 ANTAGONIST 4
- 化合物 T13114
- CCR2 ANTAGONIST 4
- 226226-39-7
- CCR-2 antagonist 4,CCR2b,CCR,chemokines,chemotaxis,Inhibitor,inhibit,inflammatory,MCP-1,chronic,CCR2 antagonist 4,CC chemokine receptor,Teijin compound1,Teijin compound-1
- Benzamide, N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-
- CCR2 antagonist 4
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxo-ethyl]-3-(trifluoromethyl)benzamide
- Teijin compound 1 hydrochloride
- Teijin compound 1
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride