5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺

5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺性质、用途与生产工艺

生物活性

GSK2578215A是一种有效的选择性LRRK2 kinase抑制剂，对LRRK2 (G2019S)和LRRK2 (WT)的IC50分别为8.9 nM 和 10.9 nM。

体外研究

GSK2578215A induces a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2[G2019S] stably transfected into HEK293 cells, and induces similar dose-dependent Ser910 and Ser935 dephosphorylation of endogenous LRRK2 in mouse Swiss 3T3 cells. In SH-SY5Y cells, GSK2578215A impairs the autophagy flux by altering autophagosome–lysosome fusion, and induces mitophagy though induction of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

体内研究

In vivo, GSK2578215A (100 mg/kg i.p.) inhibits Ser910 and Ser935 phosphorylation in mouse spleen and kidney, but not in brain.

5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 上下游产品信息

上游原料

下游产品

5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-13237	5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 GSK2578215A	1285515-21-0	5mg	560元
2024/04/30	HY-13237	5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 GSK2578215A	1285515-21-0	10mM * 1mLin DMSO	616元

5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 生产厂家

 

1285515-21-0, 5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 相关搜索:

• Inhibitors
• 药靶配体
• 小分子抑制剂，天然产物
• 小分子抑制剂
• C24H18FN3O2
• 2-(苄氧基)-5-(2-氟吡啶-4-基)-N-(吡啶-3-基)苯甲酰胺
• 5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺
• 1285515-21-0
• LRRK2-kinase inhibitor USP/EP/BP
• LRRK2 inhibitor GSK2578215A
• GSK2578215A >=98% (HPLC)
• SK2578215A
• GSK2578215
• LRRK2 inhibitor GS2578215A
• CS-1790
• 5-(2-Fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide
• 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
• GSK2578215A
• BenzaMide, 5-(2-fluoro-4-pyridinyl)-2-(phenylMethoxy)-N-3-pyridinyl-
• GSK2578125A
• 5-(2-fluoro-4-pyridinyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
• 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide GSK2578215A
• 2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzaMide
• GSK2578215A, >=98%
• LRRK2-kinase inhibitor