K201 HEMIFUMARATE
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- CAS号:
- 145903-06-6
- 英文名:
- K201 hemifumarate
- 英文别名:
- JTV-519
(K201;K201 free base;JTV-519 free base;K201 hemifumarate;JTV-519 hemifumarate;JTV 519 free base,JTV519 free base;4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine;1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone;1-Propanone, 1-(2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-;1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate
- 中文名:
- K201 HEMIFUMARATE
- 中文别名:
- 化合物 T11731;化合物 JTV-519 FREE BASE
- CBNumber:
- CB92750672
- 分子式:
- C25H32N2O2S
- 分子量:
- 424.6
- MOL File:
- 145903-06-6.mol
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K201 HEMIFUMARATE化学性质
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沸点:
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615.1±55.0 °C(Predicted)
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密度:
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1.153±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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8.93±0.10(Predicted)
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颜色:
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white to beige
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BRN:
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10598851
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K201 HEMIFUMARATE性质、用途与生产工艺
JTV-519 free base (K201 free base) 是 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂。JTV-519 free base (K201 free base) 也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 free base (K201 free base) 是一种心脏保护剂，具有抗心律失常作用。
JTV-519 (K201) inhibits inward Ca
2+
movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca
2+
, 3 μM JTV-519 shows significant inhibition of Ca
2+
movement due to annexin V, and 50% inhibition is achieved at 25 μM K201.
JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment.
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Animal Model:
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Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP)
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Dosage:
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0.5 mg/kg/h
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Administration:
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Applied intraperitoneally 2 h before the surgery
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Result:
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Improved cardiac function, where the EF and FS were significantly increased.
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K201 HEMIFUMARATE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-15293B | JTV-519 hemifumarate | | 5 mg | 750元 |
| 2024/11/08 | HY-15293B | JTV-519 hemifumarate | | 10 mg | 1200元 |
145903-06-6, K201 HEMIFUMARATE 相关搜索:
- 抑制剂
- 标准品
- 化合物 JTV-519 FREE BASE
- 化合物 T11731
- 145903-06-6
- JTV 519 free base,JTV519 free base
- 1-Propanone, 1-(2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-
- K201 free base
- JTV-519 free base
- JTV-519
(K201
- 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)propan-1-one(K201 hemifumarate)
- 4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
- 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
- K201 hemifumarate
- JTV-519 hemifumarate
- 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate