TX1-85-1
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- CAS号:
- 1603845-32-4
- 英文名:
- TX-85-1
- 英文别名:
- TX-85-1;TX1-85-1;TX-85-1, ErbB3;inhibit,TX1851,ErbB-1,Epidermal growth factor receptor,Inhibitor,HER1,TX1 85 1,TX-1-85-1,EGFR;N-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide;N-(5-{1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxyphenyl)prop-2-enamide;2-Propenamide, N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]-;TX-85-1 ? N-(5-{1-[4-(4-Acetyl-piperazin-1-yl)-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxy-phenyl)-acrylamide
- 中文名:
- TX1-85-1
- 中文别名:
- 化合物TX1-85-1;N-(5-(1-(4-(4-乙酰基哌嗪-1-基)环己基)-4-氨基-1H-吡唑并[3,4-D]嘧啶-3-基)-2-苯氧基苯基)丙烯酰胺
- CBNumber:
- CB93165813
- 分子式:
- C32H36N8O3
- 分子量:
- 580.68
- MOL File:
- 1603845-32-4.mol
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TX1-85-1化学性质
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沸点:
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825.5±65.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 0.2 mg/ml; DMSO: 0.2 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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12.34±0.70(Predicted)
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颜色:
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White to light yellow
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TX1-85-1性质、用途与生产工艺
TX1-85-1 是一种不可逆的 Her3 (ErbB3) 抑制剂，IC50 值为 23 nM。TX1-85-1 是第一个选择性 Her3 配体，与位于 Her3 的 ATP 结合位点的 Cys721 形成共价键。TX1-85-1诱发 Her3 蛋白部分降解，并减弱 Her3 依赖性信号传导。
TX1-85-1 possesses an anti-proliferation EC
50
s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.
TX1-85-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-100848 | TX1-85-1
TX1-85-1 | 1603845-32-4 | 1mg | 1100元 |
| 2024/08/19 | HY-100848 | TX1-85-1
TX1-85-1 | 1603845-32-4 | 5mg | 2200元 |
1603845-32-4, TX1-85-1 相关搜索:
- C32H36N8O3
- N-(5-(1-(4-(4-乙酰基哌嗪-1-基)环己基)-4-氨基-1H-吡唑并[3,4-D]嘧啶-3-基)-2-苯氧基苯基)丙烯酰胺
- 化合物TX1-85-1
- 1603845-32-4
- N-(5-{1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxyphenyl)prop-2-enamide
- N-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide
- inhibit,TX1851,ErbB-1,Epidermal growth factor receptor,Inhibitor,HER1,TX1 85 1,TX-1-85-1,EGFR
- 2-Propenamide, N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]-
- TX-85-1 ? N-(5-{1-[4-(4-Acetyl-piperazin-1-yl)-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxy-phenyl)-acrylamide
- TX-85-1, ErbB3
- TX1-85-1
- TX-85-1