146422-58-4
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- CAS号:
- 146422-58-4
- 英文名:
- CDD0102
- 英文别名:
- CDD0102;CDD0102A;CDD0102,CDD-0102;Pyrimidine, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydro-
- 中文名:
- 146422-58-4
- 中文别名:
- 化合物 T10731
- CBNumber:
- CB93339638
- 分子式:
- C8H12N4O
- 分子量:
- 180.21
- MOL File:
- 146422-58-4.mol
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146422-58-4化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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146422-58-4性质、用途与生产工艺
CDD0102 是一种有效的 M1 毒蕈碱 (Muscarinic) 受体激动剂。
CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M
1
receptors. CDD0102 displays much lower activity at M
3
and M
5
receptors.
After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD
50
of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose.
146422-58-4
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上游原料
下游产品
146422-58-4, 146422-58-4 相关搜索:
- 化合物 T10731
- 146422-58-4
- CDD0102,CDD-0102
- Pyrimidine, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydro-
- CDD0102A
- CDD0102