222318-55-0
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- CAS号:
- 222318-55-0
- 英文名:
- Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)-
- 英文别名:
- (4E)-SUN9221;(4E)-SUN-9221,(4E)SUN9221,(4E) SUN9221;Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)-
- 中文名:
- 222318-55-0
- 中文别名:
- 化合物 T12596
- CBNumber:
- CB93339704
- 分子式:
- C25H31FN4O3
- 分子量:
- 454.5370432
- MOL File:
- 222318-55-0.mol
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222318-55-0化学性质
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沸点:
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661.7±55.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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11.20±0.20(Predicted)
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222318-55-0性质、用途与生产工艺
(4E)-SUN9221 是一种有效的 α1-adrenergic receptor 和 5-HT2 receptor 拮抗剂,具有抗高血压和抗血小板聚集的功效。
(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC
50
s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22).
(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR.
222318-55-0
上下游产品信息
上游原料
下游产品
222318-55-0, 222318-55-0 相关搜索:
- 化合物 T12596
- 222318-55-0
- (4E)-SUN-9221,(4E)SUN9221,(4E) SUN9221
- (4E)-SUN9221
- Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)-