MD2-IN-1
|
|
- CAS号:
- 111797-22-9
- 英文名:
- MD2-IN-1
- 英文别名:
- MDK7229;MDK 7229;MD2-IN-1;MD2 inhibitor 1;MD2-IN-1; MDK7229; MDK 7229; MDK 7229;2-Propen-1-one, 1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-;inhibit,Inhibitor,MD2IN1,Toll-like Receptor (TLR),MD-2-IN-1,MD2 IN 1
- 中文名:
- MD2-IN-1
- 中文别名:
- MD2-IN-1游离;化合物MD2-IN-1
- CBNumber:
- CB93373067
- 分子式:
- C20H22O6
- 分子量:
- 358.39
- MOL File:
- 111797-22-9.mol
|
|
|
MD2-IN-1化学性质
-
熔点:
-
131-132 °C
-
|
-
沸点:
-
521.3±50.0 °C(Predicted)
-
|
-
密度:
-
1.156±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 50 mg/mL (139.51 mM);Water : < 0.1 mg/mL (insoluble)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Light yellow to yellow
-
|
MD2-IN-1性质、用途与生产工艺
MD2-IN-1是髓样分化蛋白2(MD2)的抑制剂,KD值为189 μM。
Target | Value |
MD2
()
|
189 μM(Kd)
|
Myeloid differentiation protein 2 (MD2) is a co-receptor of TLR4. Among those derivatives, MD2-IN-1 (compound 20) shows the strongest inhibitory effect on LPS-induced expression of both TNF-α and IL-6. Compare to the vehicle, LPS alone largely increases the amount of TLR4/MD2 complex, while pretreatment with MD2-IN-1 inhibits the increase of TLR4/MD2 complex to the vehicle level. SPR analysis shows that MD2-IN-1 exhibits recognizable binding to rhMD2 protein in a dose-dependent manner, with a KD value of 189 μM, while the KD value of xanthohumol binding to MD2 is 460 μM. Pre-treatment with different doses of MD2-IN-1 dose-dependently reduces FITC-LPS binding to MD2 in cell surface membranes, with a 65% inhibition at 10 μM in terms of mean fluorescence intensity. Pretreatment with MD2-IN-1 also dose-dependently blocks LPS-induced MAPK phosphorylation in the MPMs.
Administration of MD2-IN-1 evidently reduces the LPS-induced increase in protein concentrations in BALF. The lung wet/dry weight ratio is markedly higher in the LPS-treated group than the control group, and MD2-IN-1 treatment reduces LPS-induced pulmonary edema. LPS also causes observable lung histopathologic changes, including areas of inflammatory infiltration, hemorrhage, interstitial edema, thickening of the alveolar wall, and lung tissue destruction. These histopathological changes are ameliorated in the MD2-IN-1 treatment group.
MD2-IN-1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-103483 | MD2-IN-1 MD2-IN-1 | 111797-22-9 | 1mg | 800元 |
2024/04/30 | S6573 | MD2-IN-1 MD2-IN-1 | 111797-22-9 | 2mg | 1368.7元 |
111797-22-9, MD2-IN-1 相关搜索:
- 药靶配体
- MD2-IN-1游离
- 化合物MD2-IN-1
- 111797-22-9
- inhibit,Inhibitor,MD2IN1,Toll-like Receptor (TLR),MD-2-IN-1,MD2 IN 1
- 2-Propen-1-one, 1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-
- MDK7229
- MDK 7229
- MD2-IN-1; MDK7229; MDK 7229; MDK 7229
- MD2 inhibitor 1
- MD2-IN-1