依法克生
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- CAS号:
- 89197-00-2
- 英文名:
- EFAROXAN HYDROCHLORIDE
- 英文别名:
- RX 821037A;EfaroxanHCl;Zinc00002748;PO20090827-Efaroxan;EFAROXAN HYDROCHLORIDE;(+/-)-efaroxan hydrochloride;Efaroxan hydrochloride >=98% (HPLC);2-ETHYL-2-(IMIDAZOLIN-2-YL)-2,3-DIHYDROBENZOFURAN HYDROCHLORIDE;2-(2-ETHYL-2,3-DIHYDROBENZOFURAN-2-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HCL;2-(2-Ethyl-2,3-dihydrobenzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
- 中文名:
- 依法克生
- 中文别名:
- 盐酸盐依法克生;依法克生 盐酸盐;化合物 T22760;PO20090827-EFAROXAN
- CBNumber:
- CB9376896
- 分子式:
- C13H17ClN2O
- 分子量:
- 252.74
- MOL File:
- 89197-00-2.mol
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依法克生化学性质
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储存条件:
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Store at RT
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溶解度:
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H2O: 300 mg/mL
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形态:
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solid
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颜色:
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White
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水溶解性:
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Soluble to 100 mM in water
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
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依法克生性质、用途与生产工艺
Efaroxan hydrochloride 是一种有效的，选择性的，具有口服活性的 α2 肾上腺素受体 (α2-adrenoceptor) 拮抗剂，具有抗糖尿病的活性。Efaroxan hydrochloride 是一种选择性的 I1 咪唑啉受体 (I1-Imidazoline receptor) 拮抗剂，可用于心血管疾病的研究。
α2-adrenoceptor, I1-Imidazoline receptor
Efaroxan hydrochloride binds to I1-imidazoline and α2-adrenergic receptors in bovine rostral ventrolateral medulla membranes, with K
i
s of 0.15 nM and 5.6 nM, respectively
Efaroxan hydrochloride increases plasma insulin levels in both conscious fed and fasted rats without greatly affecting plasma glucoselevels.
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Animal Model:
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Male Sprague-Dawley rats (weight range 250-300g)
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Dosage:
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1 mg/kg, 5 mg/kg
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Administration:
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Oral administration
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Result:
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Produced a significant increase in plasma insulin levels of starved rats 15 and 30 min after treatment.
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依法克生
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-B1416A | 依法克生
Efaroxan hydrochloride | 89197-00-2 | 5 mg | 700元 |
| 2024/11/08 | HY-B1416A | 依法克生
Efaroxan hydrochloride | 89197-00-2 | 10 mg | 980元 |
依法克生
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89197-00-2, 依法克生 相关搜索:
- Adrenoceptor
- 抑制剂
- 药靶配体
- 黄金产品
- 88917-00-2
- 依法克生 盐酸盐
- 化合物 T22760
- PO20090827-EFAROXAN
- 盐酸盐依法克生
- 89197-00-2
- Efaroxan hydrochloride >=98% (HPLC)
- (+/-)-efaroxan hydrochloride
- PO20090827-Efaroxan
- 2-(2-ETHYL-2,3-DIHYDROBENZOFURAN-2-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HCL
- 2-(2-Ethyl-2,3-dihydrobenzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
- 2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
- 1H-Imidazole,2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-,monohydrochloride
- RX 821037A
- Zinc00002748
- RX 821037A, 2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran hydrochloride
- EfaroxanHCl
- (+/-)-2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
- 2-ETHYL-2-(IMIDAZOLIN-2-YL)-2,3-DIHYDROBENZOFURAN HYDROCHLORIDE
- EFAROXAN HYDROCHLORIDE