KSC-34
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- CAS号:
- 2226201-97-2
- 英文名:
- KSC-34
- 英文别名:
- KSC-34;PDIA1 inhibitor KSC-34;Acetamide, 2-chloro-N-[2-[[4-[methyl(4-phenylbutyl)amino]-6-(2-propyn-1-ylamino)-1,3,5-triazin-2-yl]amino]ethyl]-
- 中文名:
- KSC-34
- 中文别名:
- CBNumber:
- CB94668117
- 分子式:
- C21H28ClN7O
- 分子量:
- 429.95
- MOL File:
- 2226201-97-2.mol
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KSC-34化学性质
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密度:
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1.265±0.06 g/cm3(Predicted)
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储存条件:
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4°C, stored under nitrogen
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溶解度:
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DMSO: 100 mg/mL (232.59 mM)
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形态:
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Solid
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酸度系数(pKa):
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13.79±0.46(Predicted)
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颜色:
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White to off-white
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KSC-34性质、用途与生产工艺
KSC-34 是蛋白质二硫键异构酶 A1 (PDIA1) 的共价修饰剂，是一种有效的 PDIA1 a位点选择性抑制剂，IC50 为 3.5 μM。KSC-34 对 a′ 结构域的选择性为 30 倍。KSC-34 在复杂蛋白质组中对 PDIA 表现出选择性。
IC50: 3.5 μM (a active site of PDIA1), 104.5 μM (a′ active site of PDIA1)
KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1.
KSC-34
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-117570 | KSC-34 | | 1 mg | 1363元 |
| 2024/08/19 | HY-117570 | KSC-34
KSC-34 | 2226201-97-2 | 5mg | 3000元 |
2226201-97-2, KSC-34 相关搜索:
- 2226201-97-2
- Acetamide, 2-chloro-N-[2-[[4-[methyl(4-phenylbutyl)amino]-6-(2-propyn-1-ylamino)-1,3,5-triazin-2-yl]amino]ethyl]-
- KSC-34
- PDIA1 inhibitor KSC-34