TFLLR-NH2(TFA)
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- CAS号:
- 1313730-19-6
- 英文名:
- TFLLR-NH2(TFA)
- 英文别名:
- TFLLR-NH2(TFA);197794-83-5 (Thr1)-TRAP-5 amide;(S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate
- 中文名:
- TFLLR-NH2(TFA)
- 中文别名:
- 激动剂TFLLR-NH2;化合物 TFLLR-NH2(TFA);(S)-2-((S)-2-((2S,3R)-2-氨基-3-羟基丁酰胺基)-3-苯基丙酰胺基)-N-((S)-1-((S)-1-氨基-5-胍基-1-氧代戊-2-基)氨基)-4-甲基-1-氧代戊-2-基)-4-甲基戊酰胺 2,2,2-三氟乙酸盐
- CBNumber:
- CB94713833
- 分子式:
- C33H54F3N9O8
- 分子量:
- 761.85
- MOL File:
- 1313730-19-6.mol
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TFLLR-NH2(TFA)化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Water: 100 mg/mL (131.26 mM); DMSO: 100 mg/mL (131.26 mM)
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形态:
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Solid
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颜色:
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White to off-white
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序列:
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H-Thr-Phe-Leu-Leu-Arg-NH2
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TFLLR-NH2(TFA)性质、用途与生产工艺
TFLLR-NH2 (TFA) 是选择性的 PAR1 激动剂,EC50 值为 1.9 μM。
PAR1 agonists stimulate concentration-dependent increases in [Ca
2+
]i and in the proportions of neurones. The maximal increase in [Ca
2+
]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the
in vitro
platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1
−/−
mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
TFLLR-NH2(TFA)
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 1mg | 500元 |
2024/08/19 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 5mg | 1500元 |
1313730-19-6, TFLLR-NH2(TFA) 相关搜索:
- 抑制剂
- 化学试剂
- 药靶配体
- 目录肽
- 目录多肽
- 多肽
- 多肽
- 化合物 TFLLR-NH2(TFA)
- 激动剂TFLLR-NH2
- (S)-2-((S)-2-((2S,3R)-2-氨基-3-羟基丁酰胺基)-3-苯基丙酰胺基)-N-((S)-1-((S)-1-氨基-5-胍基-1-氧代戊-2-基)氨基)-4-甲基-1-氧代戊-2-基)-4-甲基戊酰胺 2,2,2-三氟乙酸盐
- 1313730-19-6
- (S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate
- 197794-83-5 (Thr1)-TRAP-5 amide
- TFLLR-NH2(TFA)