网站主页 >> CAS数据库列表 >> 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
|
|
|
- CAS号:
- 516480-79-8
- 英文名:
- CHK2 INHIBITOR II
- 英文别名:
- C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;C 3742 BML-277;BML-277 (C 3742);Chk2 Inhibitor II hydrate;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II (BML-277)
- 中文名:
- 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
- 中文别名:
- 化合物BML-277;CHK2 抑制剂 II;BML-277 抑制剂;CHK2INHIBITORⅡ;激酶2(CHK2)抑制剂(BML-277);2-[4-(4-氯苯氧基)苯基]-1H-苯并咪唑-5-甲酰胺;2-(4-(4-氯苯氧基)苯基)-1H-苯并[D]咪唑-6-甲酰胺;CHK2INHIBITORIIHYDRATE>=98%(HPLC)
- CBNumber:
- CB9503256
- 分子式:
- C20H14ClN3O2
- 分子量:
- 363.8
- MOL File:
- 516480-79-8.mol
|
|
|
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE化学性质
-
沸点:
-
637.1±63.0 °C(Predicted)
-
|
-
密度:
-
1.390±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: 18 mg/mL
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
10.40±0.10(Predicted)
-
|
-
颜色:
-
tan
-
|
-
稳定性:
-
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
-
|
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE性质、用途与生产工艺
Chk2 Inhibitor II (BML-277) 是一种Chk2的ATP竞争性抑制剂，IC50为15 nM。它对Chk2的选择性比对Chk1和Cdk1/B激酶高1000倍以上。Chk2 Inhibitor II (BML-277) 剂量依赖性地保护人CD4(+)和CD8(+)T细胞免受电离辐射导致的凋亡。
| Target | Value |
Chk2
(Cell-free assay)
|
15 nM
|
CHK2 Inhibitor II对Chk2丝氨酸/苏氨酸激酶的选择性比对Cdk1/B和CK1激酶的选择性高1000倍，是一种有效的、选择性的小分子抑制剂，对人类T细胞具有辐射防护作用。将CHK2 inhibitor II和ERK抑制剂组合给药比其单独给药引起更多的细胞凋亡。
对SUDHL6 DLBCL移植瘤小鼠每隔一天就腹腔注射一次vehicle、ERK inhibitor (5 mg/kg)、CHK2 inhibitor II (1 mg/kg)或组合给药，连续20天，没有发现致死性队形、显著的体重下降或是明显异常。5 mg/kg ERK inhibitor和1 mg/kg CHK2 inhibitor II可适度地抑制肿瘤生长，但组合给药的效果更加明显。
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-13946 | BML-277 | | 1 mg | 192元 |
| 2024/11/08 | S8632 | 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
Chk2 Inhibitor II (BML-277) | 516480-79-8 | 5mg | 795.32元 |
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
生产厂家
516480-79-8, 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE 相关搜索:
- API
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 抑制剂
- CHK2INHIBITORⅡ
- 化合物BML-277
- 2-(4-(4-氯苯氧基)苯基)-1H-苯并[D]咪唑-6-甲酰胺
- CHK2 抑制剂 II
- CHK2INHIBITORIIHYDRATE>=98%(HPLC)
- BML-277 抑制剂
- 激酶2(CHK2)抑制剂(BML-277)
- 2-[4-(4-氯苯氧基)苯基]-1H-苯并咪唑-5-甲酰胺
- 516480-79-8
- Chk2InhibitorⅡ
- inhibit,Checkpoint Kinase (Chk),Inhibitor,BML277,BML-277,Apoptosis
- 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide
- 1H-Benzimidazole-6-carboxamide, 2-[4-(4-chlorophenoxy)phenyl]-
- Chk2 Inhibitor II (BML-277)
- 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
- InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
- Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
- CHK2 INHIBITOR II; C 3742; BML277; BML 277
- BML-277,CHK2 INHIBITOR II
- CS-1761
- BML-277 (C 3742)
- BML-277, >98%
- 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, >98%
- Chk2 Inhibitor II hydrate
- 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
- 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide
- InSolution? Chk2 Inhibitor II
- C 3742 BML-277
- 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide
- 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
- BML-277
- C 3742