ANTI-VEGF抗体

ANTI-VEGF抗体性质、用途与生产工艺

描述

多克隆抗vegf抗体

种属反应性

Human, Mouse, Rat

偶联物

Unconjugated

制备

Produced in rabbits immunized with purified, recombinant Human VEGF121/VEGFA (rh VEGF121/VEGFA; Catalog#10008-HNAB; P15692-9; Met 1-Arg 147). VEGF121/VEGFA specific IgG was purified by Human VEGF121/VEGFA affinity chromatography.

验证的应用

WB, IHC-P

品牌示例

义翘神州
Anti-VEGF121 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate
Lysates/proteins at 30 μg per lane.

背景

VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

靶点简介

血管内皮生长因子（vascular endothelial growth factor，VEGF），又称血管通透因子（vascular permeability factor，VPF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。 血管内皮生长因子是一个家族，包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子（PGF）。通常VEGF即VEGF-A。VEGF-A可促进新生血管形成和使血管通透性增加，VEGF-B在非新生血管形成的肿瘤中起作用，VEGF-C和VEGF-D在癌组织的新生血管和新生淋巴管的形成过程中起作用，VEGF-E也是一种潜在的新生血管形成因子，PGF促进新生血管形成，使血管通透性增加，在实验性脉络膜新生血管中PGF的表达明显增高。

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ANTI-VEGF抗体 相关搜索:

• ANTI-VEGF抗体
• Anti-VEGF Antibody