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A2764 dihydrochloride - TRESK inhibitor A2764
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- CAS号:
- 861038-72-4
- 英文名:
- A2764 dihydrochloride - TRESK inhibitor A2764
- 英文别名:
- A2764 2HCL;A2764 diHCl;A2764 (hydrochloride);A2764 dihydrochloride;A2764 dihydrochloride - TRESK inhibitor A2764;2-((5-Chloroquinolin-8-yl)oxy)-N,N-diethylethanamine dihydrochloride;nociception,A-2764 dihydrochloride,A2764,inhibit,current,A2764 dihydrochloride,KcsA,A-2764,Potassium Channel,migraine,Inhibitor,A 2764,TRESK
- 中文名:
- A2764 dihydrochloride - TRESK inhibitor A2764
- 中文别名:
- A2764二盐酸盐;A2764 DIHYDROCHLORIDE;化合物A2764 DIHYDROCHLORIDE;2-((5-氯喹啉-8-基)氧基)-N,N-二乙基乙胺二盐酸盐
- CBNumber:
- CB95830973
- 分子式:
- C15H20Cl2N2O
- 分子量:
- 315.24
- MOL File:
- 861038-72-4.mol
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A2764 dihydrochloride - TRESK inhibitor A2764化学性质
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熔点:
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184-185 °C
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO: 41.67 mg/mL (118.48 mM)
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形态:
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A solid
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颜色:
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Light yellow to yellow
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A2764 dihydrochloride - TRESK inhibitor A2764性质、用途与生产工艺
A2764 dihydrochloride 是一种 TRESK (TWIK-related spinal cord K+ channel, K2P18.1) 的选择性抑制剂，对激活的mTRESK通道的IC50值为11.8 μM。A2764 dihydrochloride 具有探测TRESK通道在偏头痛和伤害感受中的作用的潜力。
| Target | Value |
activated mTRESK channel
(Cell-free assay)
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11.8 μM
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A2764 (100 µM) inhibits the background K
+
current by 42.8±11.5% when it applies to the oocytes expressing mTRESK.A2764 (100 µM) shows an improved inhibitory potency for activated channel with an IC
50
of activated channel in ionomycin-activated mTRESK current.The subsequent application of A2764 strongly inhibits the current (77.8±3.5%).
A2764 (100 µM) inhibits the current of TRESK under resting conditions and in the activated state by 42.8±11.5% and 77.8±3.5%, respectively.
A2764 dihydrochloride - TRESK inhibitor A2764
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135809 | A2764 dihydrochloride | | 1 mg | 300元 |
| 2024/04/30 | HY-135809 | A2764 dihydrochloride | | 5 mg | 750元 |
A2764 dihydrochloride - TRESK inhibitor A2764
生产厂家
861038-72-4, A2764 dihydrochloride - TRESK inhibitor A2764 相关搜索:
- 药靶配体
- A2764二盐酸盐
- 2-((5-氯喹啉-8-基)氧基)-N,N-二乙基乙胺二盐酸盐
- 化合物A2764 DIHYDROCHLORIDE
- A2764 DIHYDROCHLORIDE
- 861038-72-4
- A2764 2HCL
- A2764 (hydrochloride)
- nociception,A-2764 dihydrochloride,A2764,inhibit,current,A2764 dihydrochloride,KcsA,A-2764,Potassium Channel,migraine,Inhibitor,A 2764,TRESK
- A2764 diHCl
- 2-((5-Chloroquinolin-8-yl)oxy)-N,N-diethylethanamine dihydrochloride
- A2764 dihydrochloride
- A2764 dihydrochloride - TRESK inhibitor A2764