SPOP-IN-6b
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- CAS号:
- 2136270-20-5
- 英文名:
- SPOP-IN-6b
- 英文别名:
- SPOP-IN-6b;2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide;2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-
- 中文名:
- SPOP-IN-6b
- 中文别名:
- 化合物 T16922;化合物SPOP-IN-6B
- CBNumber:
- CB95848745
- 分子式:
- C28H32N6O3
- 分子量:
- 500.59
- MOL File:
- 2136270-20-5.mol
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SPOP-IN-6b化学性质
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 10 mg/mL (19.98 mM)
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酸度系数(pKa):
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11.90±0.20(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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SPOP-IN-6b性质、用途与生产工艺
SPOP-IN-6b 是一种 SPOP 抑制剂，来自专利 CN 107141287，化合物 SPOP-B-88。
SPOP-IN-6b a SPOP inhibitor with an IC
50
of 3.58 μM in cell assay.
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination.
Cell Viability Assay
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Cell Line:
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A498 cells
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Concentration:
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0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM
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Incubation Time:
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10 hours
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Result:
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Suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
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SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP.
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Animal Model:
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Nude mice
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Dosage:
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40 mg/kg, 60 mg/kg, 80 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 25 days
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Result:
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Slowed down the growth of tumour by suppressing SPOP.
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SPOP-IN-6b
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-122615 | SPOP-IN-6b | | 1 mg | 1333元 |
| 2024/04/30 | HY-122615 | SPOP-IN-6b
SPOP-IN-6b | 2136270-20-5 | 5mg | 3500元 |
2136270-20-5, SPOP-IN-6b 相关搜索:
- 化合物SPOP-IN-6B
- 化合物 T16922
- 2136270-20-5
- 2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
- 2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-
- SPOP-IN-6b