3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
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- CAS号:
- 2109805-87-8
- 英文名:
- FEN1 Inhibitor C3
- 英文别名:
- FEN1-IN-3;FEN1 Inhibitor C3;3-Hydroxy-1-(4-methoxyphenyl)quinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-(4-methoxyphenyl)-
- 中文名:
- 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
- 中文别名:
- 化合物 T9147;3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
- CBNumber:
- CB95864132
- 分子式:
- C15H12N2O4
- 分子量:
- 284.27
- MOL File:
- 2109805-87-8.mol
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3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO: 250 mg/mL (879.45 mM)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮性质、用途与生产工艺
FEN1-IN-3 (Compound 4) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。FEN1-IN-3 可使 hFEN1 稳定化，EC50 为 6.8 μM。
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in
Cdc4
and
Mre11a
, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
FEN1-IN-3 | 2109805-87-8 | 5mg | 790元 |
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
FEN1-IN-3 | 2109805-87-8 | 10mM * 1mLin DMSO | 869元 |
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
生产厂家
2109805-87-8, 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 相关搜索:
- 化合物 T9147
- 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
- 2109805-87-8
- 3-Hydroxy-1-(4-methoxyphenyl)quinazoline-2,4(1H,3H)-dione
- 2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-(4-methoxyphenyl)-
- FEN1-IN-3
- FEN1 Inhibitor C3