网站主页 >> CAS数据库列表 >> [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
|
|
- CAS号:
- 459836-30-7
- 英文名:
- PEAQX TETRASODIUM HYDRATE
- 英文别名:
- PEAQX TETRASODIUM HYDRATE;NVP-AAM077 tetrasodiuM hydrate;NVP-AAM 077 tetrasodiuM hydrate;[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- 中文名:
- [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- 中文别名:
- 化合物 PEAQX TETRASODIUM HYDRATE
- CBNumber:
- CB9830493
- 分子式:
- C34H32Br2N6Na4O11P2
- 分子量:
- 1014.366082
- MOL File:
- Mol file
|
|
|
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE化学性质
-
密度:
-
1.639±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
1.19±0.10(Predicted)
-
|
-
颜色:
-
Light yellow to khaki
-
|
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE性质、用途与生产工艺
PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂,其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。
PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.
PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F
3, 73
=4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.
Animal Model:
|
Timed, day 14 pregnant female Sprague-Dawley rats.
|
Dosage:
|
10, 20 or 40 mg/kg.
|
Administration:
|
S.C.
|
Result:
|
Showed a sensitized locomotor response to PCP challenge on PN28-35.
|
Animal Model:
|
Timed, day 14 pregnant female Sprague-Dawley rats.
|
Dosage:
|
4 mg/kg.
|
Administration:
|
I.P.
|
Result:
|
Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
|
Animal Model:
|
11-week old C57BL/6 mice.
|
Dosage:
|
10 mg/kg.
|
Administration:
|
IP.
|
Result:
|
Reversed the effect of PRE084 (F
3,78
= 10.446, p<0.01).
|
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-12294A | PEAQX tetrasodium hydrate | | 1 mg | 545元 |
2024/08/19 | HY-12294A | [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE PEAQX tetrasodium hydrate | 459836-30-7 | 5mg | 1200元 |
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
生产厂家
459836-30-7, [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 相关搜索:
- CHBrNNaOP
- 化合物 PEAQX TETRASODIUM HYDRATE
- 459836-30-7 (FREE BASE)
- NVP-AAM077 tetrasodiuM hydrate
- NVP-AAM 077 tetrasodiuM hydrate
- [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- PEAQX TETRASODIUM HYDRATE