网站主页 >> CAS数据库列表 >> [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
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- CAS号:
- 459836-30-7
- 英文名:
- PEAQX TETRASODIUM HYDRATE
- 英文别名:
- PEAQX TETRASODIUM HYDRATE;NVP-AAM077 tetrasodiuM hydrate;NVP-AAM 077 tetrasodiuM hydrate;[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- 中文名:
- [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- 中文别名:
- 化合物 PEAQX TETRASODIUM HYDRATE
- CBNumber:
- CB9830493
- 分子式:
- C34H32Br2N6Na4O11P2
- 分子量:
- 1014.366082
- MOL File:
- Mol file
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[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE化学性质
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密度:
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1.639±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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形态:
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Solid
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酸度系数(pKa):
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1.19±0.10(Predicted)
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颜色:
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Light yellow to khaki
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[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE性质、用途与生产工艺
PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。
PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.
PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F
3, 73
=4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.
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Animal Model:
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Timed, day 14 pregnant female Sprague-Dawley rats.
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Dosage:
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10, 20 or 40 mg/kg.
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Administration:
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S.C.
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Result:
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Showed a sensitized locomotor response to PCP challenge on PN28-35.
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Animal Model:
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Timed, day 14 pregnant female Sprague-Dawley rats.
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Dosage:
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4 mg/kg.
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Administration:
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I.P.
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Result:
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Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
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Animal Model:
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11-week old C57BL/6 mice.
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Dosage:
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10 mg/kg.
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Administration:
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IP.
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Result:
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Reversed the effect of PRE084 (F
3,78
= 10.446, p<0.01).
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[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-12294A | PEAQX tetrasodium hydrate | | 1 mg | 545元 |
| 2024/08/19 | HY-12294A | [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
PEAQX tetrasodium hydrate | 459836-30-7 | 5mg | 1200元 |
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
生产厂家
459836-30-7, [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 相关搜索:
- CHBrNNaOP
- 化合物 PEAQX TETRASODIUM HYDRATE
- 459836-30-7 (FREE BASE)
- NVP-AAM077 tetrasodiuM hydrate
- NVP-AAM 077 tetrasodiuM hydrate
- [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
- PEAQX TETRASODIUM HYDRATE