3-羧基地托咪定
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- CAS号:
- 115664-39-6
- 英文名:
- 3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
- 英文别名:
- 3-Carboxy DetoMidine;Detomidine carboxylic acid;detomidine 3-carboxylic acid;3-(1H-IMidazol-5-ylMethyl)-2-Methylbenzoic Acid;3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID;Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-
- 中文名:
- 3-羧基地托咪定
- 中文别名:
- 地托米定羧酸;3-羧基地托咪定
- CBNumber:
- CB9840865
- 分子式:
- C12H12N2O2
- 分子量:
- 216.24
- MOL File:
- 115664-39-6.mol
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3-羧基地托咪定化学性质
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沸点:
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499.6±33.0 °C(Predicted)
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密度:
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1.278±0.06 g/cm3(Predicted)
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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3.83±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to Pale Brown
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3-羧基地托咪定性质、用途与生产工艺
Detomidine carboxylic acid 是 Detomidine 的主要尿代谢产物。Detomidine 是一种合成的 α2-肾上腺素能 (α2-adrenergic) 激动剂，也是一种动物镇痛镇静剂。Detomidine 还具有心脏和呼吸作用以及抗利尿作用。
Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [
3
H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [
3
H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected.
3-羧基地托咪定
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115664-39-6, 3-羧基地托咪定 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- 地托米定羧酸
- 3-羧基地托咪定
- 115664-39-6
- Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-
- Detomidine carboxylic acid
- 3-Carboxy DetoMidine
- detomidine 3-carboxylic acid
- 3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
- 3-(1H-IMidazol-5-ylMethyl)-2-Methylbenzoic Acid