2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

1572936-83-4

CAS-Nr.: 1572936-83-4

Englisch Name:: 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

Synonyma:: Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-

CBNumber:: CB63049204

Summenformel:: C18H14N2O5

Molgewicht:: 338.31

MOL-Datei:: 1572936-83-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 35

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Eigenschaften

Siedepunkt:: 553.1±50.0 °C(Predicted)

Dichte: 1.421±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble

Aggregatzustand: A crystalline solid

pka: 2.26±0.22(Predicted)

Farbe: Brown to dark brown

Sicherheit

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC₅₀ = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Verwenden

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 35)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	sales@zhiwe.net	China	623	61
Nanjing Chemlin Chemical Co., Ltd	025-83697070	info@chemlin.com.cn	China	19169	64
AN PharmaTech Co Ltd	86(21)68097365	sales@anpharma.net	China	4901	55
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel
1572936-83-4