XAP044

196928-50-4

CAS-Nr.: 196928-50-4

Englisch Name:: XAP044

Synonyma:: XAP044;7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-;XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044

CBNumber:: CB73152769

Summenformel:: C15H9IO4

Molgewicht:: 380.13

MOL-Datei:: 196928-50-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 40

XAP044 Eigenschaften

Siedepunkt:: 485.7±45.0 °C(Predicted)

Dichte: 1.853±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: ≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

Aggregatzustand: crystalline solid

pka: 6.70±0.20(Predicted)

Sicherheit

XAP044 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC₅₀ value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.

Verwenden

XAP 044 is a potent mGlu7 antagonist used in the treatment of anxiety and depression in mice (1,2). Applications towards stress, autism and drug abuse are also potential uses.

XAP044 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

XAP044 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 40)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Block Chemical Technology (Shanghai) Co., LTD	021-20432219 13918097649	li_jinfei@acblock-lab.com	China	9562	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	996	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	18779	58

XAP044
7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-
7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
196928-50-4
C15H9IO4