TIROFIBAN HYDROCHLORIDE MONOHYDRATE
- CAS No.
- 142373-60-2
- Chemical Name:
- TIROFIBAN HYDROCHLORIDE MONOHYDRATE
- Synonyms
- Tirofiban Hydrochloride;butoxy);L 700462;4-Dihydroxypyridine;-3-(4-(4-(piperidin-4-yl);TirofibanhydrochlorideHCl;Tirofiban hydrochloride 1-hydrate;Tirofiban hydrochloride (L700462);Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride
- CBNumber:
- CB0100160
- Molecular Formula:
- C22H39ClN2O6S
- Molecular Weight:
- 495.07
- MDL Number:
- MFCD00868210
- MOL File:
- 142373-60-2.mol
- MSDS File:
- SDS
| Melting point | 83-87oC |
|---|---|
| solubility | Methanol (Slightly) |
| form | Solid |
| color | White |
| CAS DataBase Reference | 142373-60-2 |
| EWG's Food Scores | 1 |
| FDA UNII | IKE1P4X57J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
TIROFIBAN HYDROCHLORIDE MONOHYDRATE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0014445 | TIROFIBAN HYDROCHLORIDE 95.00% | 142373-60-2 | 5MG | $501.15 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 53173 | TirofibanHCl | 142373-60-2 | 10mg | $570 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014445 | TIROFIBAN HYDROCHLORIDE 95.00% | 142373-60-2 | 250MG | $898.8 | 2021-12-16 | Buy |
| Chemenu | CM195483 | (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride 97% | 142373-60-2 | 1g | $1117 | 2021-12-16 | Buy |
| Crysdot | CD21014226 | (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride 97% | 142373-60-2 | 1g | $1186 | 2021-12-16 | Buy |
TIROFIBAN HYDROCHLORIDE MONOHYDRATE Chemical Properties,Uses,Production
Description
Tirofiban was launched as Aggrastat in Switzerland and the US for patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound glycoprotein complex. It prevents arterial thrombus formation in a dosedependent manner. Clinical efficacy was highly significant with an absolute and relative risk reduction. In these studies, treatment with tirofiban was well tolerated, without significant adverse effects.
Originator
Sibutramine (Sibutramine)
Uses
Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.
Uses
Aggrastat (Millot Laboratories, France).
Manufacturing Process
The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives the corresponding sulfonamide derivative; the quite labile silyl groups are then removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a parallel scheme, 4-picoline is converted to its anion by means of butyl lithium; this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3- chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then reduce the pyridine ring to a piperidine to afford the fibrinogen receptor antagonist tirofiban.
brand name
Tirofiban is INN and BAN.
Therapeutic Function
Fibrinogen receptor antagonist
TIROFIBAN HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 |
View Lastest Price from TIROFIBAN HYDROCHLORIDE MONOHYDRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-07 | TIROFIBAN HYDROCHLORIDE MONOHYDRATE USP/EP/BP
142373-60-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-12 | Tirofiban hydrochloride
142373-60-2
|
US $0.00-0.00 / KG | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd
|
|
 |
2019-07-06 | TIROFIBAN HYDROCHLORIDE MONOHYDRATE
142373-60-2
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- TIROFIBAN HYDROCHLORIDE MONOHYDRATE USP/EP/BP
142373-60-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Tirofiban hydrochloride
142373-60-2
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- TIROFIBAN HYDROCHLORIDE MONOHYDRATE
142373-60-2
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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