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ChemicalBook >> CAS DataBase List >>Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2)

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2)

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) Structure
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) structure
CAS No.
2320262-09-5
Chemical Name:
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2)
Synonyms
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2)
CBNumber:
CB010494709
Molecular Formula:
C20H28ClN3OS
Molecular Weight:
393.97
MDL Number:
MOL File:
2320262-09-5.mol
Last updated:2023-04-23 13:52:06
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Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) Properties

solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form A crystalline solid

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21101 RU-SKI 201 (hydrochloride) ≥95% 2320262-09-5 1 mg $61 2024-03-01 Buy
Cayman Chemical 21101 RU-SKI 201 (hydrochloride) ≥95% 2320262-09-5 5 mg $264 2024-03-01 Buy
Cayman Chemical 21101 RU-SKI 201 (hydrochloride) ≥95% 2320262-09-5 10 mg $468 2024-03-01 Buy
Product number Packaging Price Buy
21101 1 mg $61 Buy
21101 5 mg $264 Buy
21101 10 mg $468 Buy

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) Chemical Properties,Uses,Production

Description

RU-SKI 201 is an inhibitor of hedgehog acyltransferase (Hhat; IC50 = 0.2 μM for recombinant enzyme).1 It inhibits palmitoylation of sonic hedgehog (Shh) in Shh-overexpressing HEK293 cells with a tagging IC50 (TC50) value of 0.87 μM. RU-SKI 201 inhibits hedgehog (Hh) signaling in H520, PANC-1, and MCF-7 cancer cells co-cultured with Shh-Light2 cells (IC50s = 4.8, 7.8, and 8.5 μM, respectively).

References

1. Rodgers, U.R., Lanyon-Hogg, T., Masumoto, N., et al. Characterization of hedgehog acyltransferase inhibitors identifies a small molecule probe for hedgehog signaling by cancer cells ACS Chem. Biol. 11(12),3256-3262(2016).

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 18470 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:2) 2320262-09-5