Interferonbeta1a/Humaninterferonbeta1a
- CAS No.
- 145258-61-3
- Chemical Name:
- Interferonbeta1a/Humaninterferonbeta1a
- Synonyms
- IFN-beta;Interferon β-1a;Unii-xro4566Q4r;interferon beta 1a;Interferon beta-1a CRS;Interferonbeta1a/Humaninterferonbeta1a;Interferon beta1 (human fibroblast protein moiety);Interferon Beta-1A (1.0 mL) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED);Interferon Beta-1A for Bioidentity (200 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
- CBNumber:
- CB01074453
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -70°C |
|---|---|
| EWG's Food Scores | 1 |
| FDA UNII | XRO4566Q4R |
| ATC code | L03AB07 |
Interferonbeta1a/Humaninterferonbeta1a price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001101 | Interferon β-1a European Pharmacopoeia (EP) Reference Standard | 145258-61-3 | y0001101 | $248 | 2024-03-01 | Buy |
| Usbiological | 356476 | IFN-beta | 145258-61-3 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 356478 | IFN-beta | 145258-61-3 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 383346 | IFN-beta | 145258-61-3 | 96Tests | $599 | 2021-12-16 | Buy |
Interferonbeta1a/Humaninterferonbeta1a Chemical Properties,Uses,Production
Description
Launched in the US for relapsing forms of multiple sclerosis (MS), interferon β-1a is the second compound to be marketed for MS next to interferon p-lb (Betaseron). This form of p-interferon is a glycosylated polypeptide of 166 amino acids (sequence identical to human) produced from cultured Chinese hamster ovary cells containing the engineered human gene for interferon β-1a. The difference in structure to interferon β-1b lies in the substitution of a cysteine for a serine and in the fact it is glycosylated. The I b form requires reconstitution and subcutaneous injection every other day, while the l a form is an intramuscular injection once a week. The exact mode of action for the β-interferons has not been delineated, however, it is thought that they reverse a suppressor cell defect and favor the generation of T helper-2 type responses. It is presumed that the immunoregulatory and antiviral actions, in addition to the antagonistic effect they have on γ-interferon (γ-interferon has been shown to exacerbate the symptoms of MS), provide an overall beneficial effect.
Originator
Biogen (USA)
Uses
Antineoplastic; biological response modifier.
brand name
Neoferon (Biogen).
General Description
Interferon beta-1a (recombinant), Avonex, is a glycoproteinwith 166 amino acids. It has a molecular mass of approximately22,000 Da.Interferon beta-1a is indicated for the treatment of relapsingforms of MS. Patients treated with interferon beta-1ademonstrate a slower progression to disability and a less noticeablebreakdown of the blood-brain barrier as observed ingadolinium-enhanced magnetic resonance imaging (MRI). Although the exact mechanism of action of interferonbeta-1a in MS has not been elucidated, it is known that thedrug exerts its biological effects by binding to specific receptorson the surface of human cells. This binding initiatesa cascade of intracellular events that lead to the expressionof interferon-induced gene products.
Adverse effects include flulike syndrome at the start oftherapy that decreases in severity as treatment progresses.Interferon beta-1a is a potential abortifacient and an inhibitorof cytochrome P450.The dosage form is a powder for solution that is reconstitutedin sterile water. Excipients are human albumin,sodium chloride, and phosphate buffer.
Interferonbeta1a/Humaninterferonbeta1a Preparation Products And Raw materials
Raw materials
Preparation Products
Interferonbeta1a/Humaninterferonbeta1a Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10787 | 58 |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016 | 3287908757@qq.com | China | 9118 | 58 |