Interferonbeta1a/Humaninterferonbeta1a

CAS No.
145258-61-3
Chemical Name:
Interferonbeta1a/Humaninterferonbeta1a
Synonyms
IFN-beta;Interferon β-1a;Unii-xro4566Q4r;interferon beta 1a;Interferon beta-1a CRS;Interferonbeta1a/Humaninterferonbeta1a;Interferon beta1 (human fibroblast protein moiety);Interferon Beta-1A (1.0 mL) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED);Interferon Beta-1A for Bioidentity (200 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
CBNumber:
CB01074453
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

Interferonbeta1a/Humaninterferonbeta1a Properties

storage temp. -70°C
EWG's Food Scores 1
FDA UNII XRO4566Q4R
ATC code L03AB07

SAFETY

Risk and Safety Statements

RTECS  NM9701100

Interferonbeta1a/Humaninterferonbeta1a price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001101 Interferon β-1a European Pharmacopoeia (EP) Reference Standard 145258-61-3 y0001101 $248 2024-03-01 Buy
Usbiological 356476 IFN-beta 145258-61-3 48Tests $588 2021-12-16 Buy
Usbiological 356478 IFN-beta 145258-61-3 48Tests $588 2021-12-16 Buy
Usbiological 383346 IFN-beta 145258-61-3 96Tests $599 2021-12-16 Buy
Product number Packaging Price Buy
Y0001101 y0001101 $248 Buy
356476 48Tests $588 Buy
356478 48Tests $588 Buy
383346 96Tests $599 Buy

Interferonbeta1a/Humaninterferonbeta1a Chemical Properties,Uses,Production

Description

Launched in the US for relapsing forms of multiple sclerosis (MS), interferon β-1a is the second compound to be marketed for MS next to interferon p-lb (Betaseron). This form of p-interferon is a glycosylated polypeptide of 166 amino acids (sequence identical to human) produced from cultured Chinese hamster ovary cells containing the engineered human gene for interferon β-1a. The difference in structure to interferon β-1b lies in the substitution of a cysteine for a serine and in the fact it is glycosylated. The I b form requires reconstitution and subcutaneous injection every other day, while the l a form is an intramuscular injection once a week. The exact mode of action for the β-interferons has not been delineated, however, it is thought that they reverse a suppressor cell defect and favor the generation of T helper-2 type responses. It is presumed that the immunoregulatory and antiviral actions, in addition to the antagonistic effect they have on γ-interferon (γ-interferon has been shown to exacerbate the symptoms of MS), provide an overall beneficial effect.

Originator

Biogen (USA)

Uses

Antineoplastic; biological response modifier.

brand name

Neoferon (Biogen).

General Description

Interferon beta-1a (recombinant), Avonex, is a glycoproteinwith 166 amino acids. It has a molecular mass of approximately22,000 Da.Interferon beta-1a is indicated for the treatment of relapsingforms of MS. Patients treated with interferon beta-1ademonstrate a slower progression to disability and a less noticeablebreakdown of the blood-brain barrier as observed ingadolinium-enhanced magnetic resonance imaging (MRI). Although the exact mechanism of action of interferonbeta-1a in MS has not been elucidated, it is known that thedrug exerts its biological effects by binding to specific receptorson the surface of human cells. This binding initiatesa cascade of intracellular events that lead to the expressionof interferon-induced gene products.
Adverse effects include flulike syndrome at the start oftherapy that decreases in severity as treatment progresses.Interferon beta-1a is a potential abortifacient and an inhibitorof cytochrome P450.The dosage form is a powder for solution that is reconstitutedin sterile water. Excipients are human albumin,sodium chloride, and phosphate buffer.

Interferonbeta1a/Humaninterferonbeta1a Preparation Products And Raw materials

Raw materials

Preparation Products

Interferonbeta1a/Humaninterferonbeta1a Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15356 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12335 58
Nanjing Shizhou Biology Technology Co.,Ltd 13675144456 sean.lv@synzest.com China 10784 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 18162595016; 18162595016 3287908757@qq.com China 9122 58
IFN-beta Interferonbeta1a/Humaninterferonbeta1a interferon beta 1a Unii-xro4566Q4r Interferon beta1 (human fibroblast protein moiety) Interferon β-1a Interferon beta-1a CRS Interferon Beta-1A (1.0 mL) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) Interferon Beta-1A for Bioidentity (200 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) 145258-61-3