Ponazuril
- CAS No.
- 69004-04-2
- Chemical Name:
- Ponazuril
- Synonyms
- 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;Veterinary Ponazuril;Toltrazuril Sulfone Standard;Toltrazuril sulfone Ponazuril;Ponazuril ，Toltrazuril sulfone
- CBNumber:
- CB01075339
- Molecular Formula:
- C18H14F3N3O6S
- Molecular Weight:
- 457.38
- MDL Number:
- MFCD09263475
- MOL File:
- 69004-04-2.mol
| Melting point | 242° |
|---|---|
| Density | 1.507±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 6.46±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | VBUNOIXRZNJNAD-UHFFFAOYSA-N |
| CAS DataBase Reference | 69004-04-2 |
| FDA UNII | JPW84AS66U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
Ponazuril price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 33816 | Toltrazuril sulfone VETRANAL | 69004-04-2 | 10mg | $323 | 2024-03-01 | Buy |
| Cayman Chemical | 29655 | Toltrazuril sulfone | 69004-04-2 | 50mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29655 | Toltrazuril sulfone | 69004-04-2 | 250mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 29655 | Toltrazuril sulfone | 69004-04-2 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29655 | Toltrazuril sulfone | 69004-04-2 | 100mg | $169 | 2024-03-01 | Buy |
Ponazuril Chemical Properties,Uses,Production
Description
Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.
Uses
Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).
Veterinary Drugs and Treatments
Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis
(EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum
and Toxoplasma infections in dogs or cats.
Ponazuril Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 | bruce.lei@masteam.com | CHINA | 153 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 1616 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12459 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 | sales06@hbduling.cn | China | 15695 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 253 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1142 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | admin@hbouhuang.com | China | 2952 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 299 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21670 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
View Lastest Price from Ponazuril manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-29 | Ponazuril ，Toltrazuril sulfone
69004-04-2
|
US $0.00 / Kg/Bag | 2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-07-25 | Ponazuril
69004-04-2
|
US $0.00 / Kg/Drum | 1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-07-07 | Ponazuril
69004-04-2
|
US $0.10 / KG | 1KG | 98.0% | 10 | Shaanxi Dideu Medichem Co. Ltd |
-
- Ponazuril ，Toltrazuril sulfone
69004-04-2
- US $0.00 / Kg/Bag
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- Ponazuril
69004-04-2
- US $0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ponazuril
69004-04-2
- US $0.10 / KG
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
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