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Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- structure

CAS No.: 208109-38-0

Chemical Name:: Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-

Synonyms: F 14679;Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-;F 13714/F 14679/(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone

CBNumber:: CB010808605

Molecular Formula:: C21H25ClF2N4O

Molecular Weight:: 422.9

MDL Number:

MOL File:: 208109-38-0.mol

Last updated:2023-03-31 09:12:57

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Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Properties

Boiling point	583.8±50.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
pka	7.97±0.20(Predicted)

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Chemical Properties,Uses,Production

Description

F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan chuang he chemical co. LTD	15907120073	1261789306@qq.com	China	1034	58
Hefei fuya biotechnology co. LTD	18096409024	sales02@foreversyn.com	China	1978	58
Bide Pharmatech Ltd.	15221909166 13681763483	huahuanhuan@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58

Supplier	Advantage
Wuhan chuang he chemical co. LTD	58
Hefei fuya biotechnology co. LTD	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- F 14679 F 13714/F 14679/(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone 208109-38-0 C21H25ClF2N4O