Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-
- CAS No.
- 208109-38-0
- Chemical Name:
- Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-
- Synonyms
- F 14679;Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-;F 13714/F 14679/(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone
- CBNumber:
- CB010808605
- Molecular Formula:
- C21H25ClF2N4O
- Molecular Weight:
- 422.9
- MDL Number:
- MOL File:
- 208109-38-0.mol
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Chemical Properties,Uses,Production
Description
F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan chuang he chemical co. LTD | 15907120073 | 1261789306@qq.com | China | 1034 | 58 |
Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1978 | 58 |
Bide Pharmatech Ltd. | 15221909166 13681763483 | huahuanhuan@bidepharm.com | China | 63720 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Supplier | Advantage |
---|---|
Wuhan chuang he chemical co. LTD | 58 |
Hefei fuya biotechnology co. LTD | 58 |
Bide Pharmatech Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |