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Euphorbiasteroid

Euphorbiasteroid structure

CAS No.: 28649-59-4

Chemical Name:: Euphorbiasteroid

Synonyms: Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid（EuphorbiaFactor L1）;6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester

CBNumber:: CB01118210

Molecular Formula:: C32H40O8

Molecular Weight:: 552.66

MDL Number:: MFCD06410946

MOL File:: 28649-59-4.mol

MSDS File:: SDS

Last updated:2024-11-21 17:11:28

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Euphorbiasteroid Properties

Melting point	199～200℃
Boiling point	633.1±55.0 °C(Predicted)
Density	1.23
storage temp.	4°C, protect from light
solubility	DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
form	A crystalline solid

SAFETY

Risk and Safety Statements

Safety Statements	24/25
HS Code	29061990

Euphorbiasteroid price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27822	Euphorbiasteroid	28649-59-4	25mg	$121	2024-03-01	Buy
Cayman Chemical	27822	Euphorbiasteroid	28649-59-4	250mg	$961	2024-03-01	Buy
Cayman Chemical	27822	Euphorbiasteroid	28649-59-4	50mg	$230	2024-03-01	Buy
Cayman Chemical	27822	Euphorbiasteroid	28649-59-4	100mg	$411	2024-03-01	Buy
TRC	E938885	Euphorbiasteroid	28649-59-4	5mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
27822	25mg	$121	Buy
27822	250mg	$961	Buy
27822	50mg	$230	Buy
27822	100mg	$411	Buy
E938885	5mg	$55	Buy

Euphorbiasteroid Chemical Properties,Uses,Production

Uses

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Preparation Products And Raw materials

Raw materials

Preparation Products

Euphorbiasteroid Suppliers

Global( 130)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12841	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-17333973358	sales06@hbduling.cn	China	8053	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Fengjia New Material Co., Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58

Euphorbia factor L1—a multi-functional diterpenoid
Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, e....
Feb 28，2020

View Lastest Price from Euphorbiasteroid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-21	Euphorbiasteroid 28649-59-4	US $1.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-08-08	Euphorbiasteroid 28649-59-4	US $9.00 / kg	1kg	0.99	10000	Hebei Fengjia New Material Co., Ltd
2023-08-30	Euphorbiasteroid 28649-59-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Euphorbiasteroid
28649-59-4
US $1.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Euphorbiasteroid
28649-59-4
US $9.00 / kg
0.99
Hebei Fengjia New Material Co., Ltd

Euphorbiasteroid
28649-59-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

28649-59-4(Euphorbiasteroid)Related Search:

Euphorbia factor L7b beta-Sitosterol Dodecanoic acid ingenol ester Ingenol mebutate 17-Hydroxyisolathyrol

20-DEOXYINGENOL (6R)-6,6aβ,7aβ,8,9,12,12a,12bβ-Octahydro-12α,12aα-dihydroxy-2,2,7,7,9β,11-hexamethyl-7H-6β,9aβ-methano-4H-cyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d]-1,3-dioxin-13-one Euphorbia factor L1 euphorbiafactor L2 DIACETYL BENZOYL LATHYROL

Ingenol (1aR,7bR)-1aα,2,7aα,13,14,14aα-Hexahydro-1,1,6,6,9,9,11,13α-octamethyl-10aαH-2α,12aα-methano-1H,4H-cyclopropa[5,6][1,3]dioxolo[2',3']cyclopenta[1',2':9,10]cyclodeca[1,2-d][1,3]dioxin-15-one Euphorbiasteroid TRANS-CYCLODODECENE

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Daughter son sterol 6,20-Epoxylathyrol phenylacetate diacetate Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester Euphorbia factor L1 Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,... Euphorbiasteroid（EuphorbiaFactor L1） (1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate 28649-59-4 32H40O8 C32H40O8