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Spirogermanium

Spirogermanium structure

CAS No.: 41992-22-7

Chemical Name:: Spirogermanium

Synonyms: S-99A;CL76185;Spiro-32;NSC-192965;Spirogermanium;Spirogermanium compound;SPIROGERMANIUMHYDROCHLORIDE;Spriogermanium hydrochloride;2-AZA-8-GERMANSPIROL(4,5)DECANE-2-PROPAMINE-8,8-DIETHYL-N,.;2-Aza-8-germaspiro[4.5]decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-, dihydrochloride

CBNumber:: CB01179770

Molecular Formula:: C17H38Cl2GeN2

Molecular Weight:: 414.04302

MDL Number:

MOL File:: 41992-22-7.mol

Last updated:2022-12-21 16:56:50

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Spirogermanium Properties

Melting point	287-288°
FDA UNII	25S5I1P6O6
NCI Drug Dictionary	spirogermanium

SAFETY

Risk and Safety Statements

Toxicity	LD50 in rats (mg/kg): 75 i.p.; in mice (mg/kg): 150 i.p., 324 orally (Rice et al.); LD50 in male, female mice (mg/kg): 44.5, 41.5 i.v.; 142.9, 119 i.m. (Henry, 1980)

Spirogermanium price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0016397	SPIROGERMANIUM DIHYDROCHLORIDE 95.00%	41992-22-7	5MG	$496.67	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0016397	5MG	$496.67	Buy

Spirogermanium Chemical Properties,Uses,Production

Pharmaceutical Applications

2-(3-Dimethylaminopropyl)-8,8-diethyl-2-aza-8-germaspiro[4,5]decane (spirogermanium) was the first organogermanium compound tested as an anticancer agent on a wide variety of human cancer cell lines, such as ovarian, cervix, breast, renal cell cancers and others. Preclinical toxicological evaluation in white mice confirmed the lack of bone marrow toxicity.
Spirogermanium entered clinical trials and showed good drug tolerance in phase I clinical trials. Phase II clinical trials revealed consistent neurotoxicity as well as pulmonary toxicities and only moderate activity against ovarian cancer. The mode of action involved is believed to be based on the inhibition of protein synthesis and a secondary suppression of RNA and DNA synthesis.

Spirogermanium Preparation Products And Raw materials

Raw materials

Preparation Products

Spirogermanium Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Lanospharma Laboratories Co.,Ltd	--	sales@lanospharma.com	China	6329	56

Supplier	Advantage
Lanospharma Laboratories Co.,Ltd	56

CL76185 NSC-192965 S-99A Spiro-32 2-Aza-8-germaspiro[4.5]decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-, dihydrochloride Spirogermanium compound Spriogermanium hydrochloride Spirogermanium 2-AZA-8-GERMANSPIROL(4,5)DECANE-2-PROPAMINE-8,8-DIETHYL-N,. SPIROGERMANIUMHYDROCHLORIDE 41992-22-7