γ-Acetylenic GABA hydrochloride
- CAS No.
- 103451-26-9
- Chemical Name:
- γ-Acetylenic GABA hydrochloride
- Synonyms
- γ-Acetylenic GABA hydrochloride;γ-Acetylenic GABA hydrochloride, 10 mM in DMSO
- CBNumber:
- CB013251374
- Molecular Formula:
- C6H10ClNO2
- Molecular Weight:
- 163.6
- MDL Number:
- MOL File:
- 103451-26-9.mol
γ-Acetylenic GABA hydrochloride Chemical Properties,Uses,Production
Uses
γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride can increase the concentration of GABA in rat brain[1][2][3]. γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
γ-Acetylenic GABA hydrochloride (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].
References
[1] Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9. DOI:10.1001/archpsyc.1980.01780250062007
[2] Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36. DOI:10.1016/0014-2999(78)90138-3
[3] Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203. DOI:10.1002/14651858.CD000203.pub3
γ-Acetylenic GABA hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
γ-Acetylenic GABA hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19710 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 47255 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 58 |
View Lastest Price from γ-Acetylenic GABA hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | γ-Acetylenic GABA hydrochloride
103451-26-9
|
US $50.00-128.00 / mg | 99.64% | 10g | TargetMol Chemicals Inc. |
-
- γ-Acetylenic GABA hydrochloride
103451-26-9
- US $50.00-128.00 / mg
- 99.64%
- TargetMol Chemicals Inc.