Ro 41-5253
- CAS No.
- 144092-31-9
- Chemical Name:
- Ro 41-5253
- Synonyms
- Ro 41-5253;Ro 41-5253 >=98% (HPLC);4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)
- CBNumber:
- CB01329632
- Molecular Formula:
- C28H36O5S
- Molecular Weight:
- 484.65
- MDL Number:
- MFCD00926134
- MOL File:
- 144092-31-9.mol
Ro 41-5253 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0573 | Ro 41-5253 ≥98% (HPLC) | 144092-31-9 | 5mg | $64.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0573 | Ro 41-5253 ≥98% (HPLC) | 144092-31-9 | 25mg | $620 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | INB0004027 | (E)-S,S-DIOXIDE-4-(2-(7-(HEPTYLOXY)-3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)-1-PROPENYL)BENZOIC ACID 95.00% | 144092-31-9 | 5MG | $223.3 | 2021-12-16 | Buy |
Ro 41-5253 Chemical Properties,Uses,Production
Description
Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
Uses
Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.
Definition
ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.
References
1) Apfel?et al. (1992),?A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA,?89?7129 2) Toma?et al. (1998),?RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer,?78?86
Ro 41-5253 Preparation Products And Raw materials
Raw materials
Preparation Products
Ro 41-5253 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44806 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4988 | 58 |
View Lastest Price from Ro 41-5253 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Ro 41-5253
144092-31-9
|
US $52.00 / mg | 98% | 10g | TargetMol Chemicals Inc. |
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- Ro 41-5253
144092-31-9
- US $52.00 / mg
- 98%
- TargetMol Chemicals Inc.
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