Pentafluorophenol
- CAS No.
- 771-61-9
- Chemical Name:
- Pentafluorophenol
- Synonyms
- PFP;2,3,4,5,6-PENTAFLUOROPHENOL;HOPFP;PFP-OH;PENTAFLUORPHENOL;C6F5OH;Pentafluorophe;SSI(R) Unions;PERFLUOROPHENOL;Pentaflurophenol
- CBNumber:
- CB0135306
- Molecular Formula:
- C6HF5O
- Molecular Weight:
- 184.06
- MDL Number:
- MFCD00002156
- MOL File:
- 771-61-9.mol
- MSDS File:
- SDS
| Melting point | 34-36 °C (lit.) |
|---|---|
| Boiling point | 143 °C (lit.) |
| Density | 1.757 |
| refractive index | 1.4270 |
| Flash point | 162 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 5.50±0.33(Predicted) |
| form | Low Melting Crystalline Solid |
| color | White to almost white |
| Specific Gravity | 1.757 |
| Water Solubility | soluble |
| BRN | 1912584 |
| Stability | Stable. Incompatible with strong oxidizing agents, bases, acid chlorides, acid anhydrides. |
| InChIKey | XBNGYFFABRKICK-UHFFFAOYSA-N |
| CAS DataBase Reference | 771-61-9(CAS DataBase Reference) |
| FDA UNII | A2YCF0YUHA |
| NIST Chemistry Reference | Phenol, pentafluoro-(771-61-9) |
| EPA Substance Registry System | Pentafluorophenol (771-61-9) |
| UNSPSC Code | 12352104 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352+P312-P362+P364 | |||||||||
| Hazard Codes | Xi,T,C,Xn | |||||||||
| Risk Statements | 36/37/38-34-20/21/22-63-43-23/24/25-45-67-40 | |||||||||
| Safety Statements | 26-36-45-36/37/39-36/37-24/25-23-53 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SM6680000 | |||||||||
| F | 3 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| TSCA | T | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29081000 | |||||||||
| Toxicity | LD50 scu-rat: 322 mg/kg IZSBAI 3,91,65 | |||||||||
| NFPA 704 |
|
Pentafluorophenol price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 103799 | Pentafluorophenol ReagentPlus , ≥99% | 771-61-9 | 5g | $42.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 103799 | Pentafluorophenol ReagentPlus , ≥99% | 771-61-9 | 10g | $78.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18100 | Pentafluorophenol for synthesis | 771-61-9 | 25g | $162 | 2022-05-15 | Buy |
| TCI Chemical | P0919 | Pentafluorophenol >98.0%(GC)(T) | 771-61-9 | 10g | $50 | 2024-03-01 | Buy |
| TCI Chemical | P0919 | Pentafluorophenol >98.0%(GC)(T) | 771-61-9 | 25g | $103 | 2024-03-01 | Buy |
Pentafluorophenol Chemical Properties,Uses,Production
Description
Pentafluorophenol can be used for the preparation of penta-fluorophenyl esters for peptide synthesis. It is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids. It can be used for synthesizing novel reagents which can achieve highly diastereoselective acetal cleavage.
Reference
3. Ishihara, Kazuaki, N. Hanaki, and H. Yamamoto. "Highly diastereoselective acetal cleavages using novel reagents prepared from organoaluminum and pentafluorophenol" Cheminform 25.9(2010):no-no.
Chemical Properties
White solid
Uses
For the preparation of pentafluorophenyl esters for peptide synthesis.
Uses
Used for the preparation of pentafluorophenyl esters for peptide synthesis
Uses
Pentafluorophenol is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids.
Application
Pentafluorophenol can be used as a reactant to synthesize pentafluorophenyl esters from:
- N-protected amino acid in the presence of dicyclohexylcarbodiimide and ethyl acetate.
- t-Butoxycarbonyl-L-alanylglycinein the presence of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride.
- Aliphatic dicarboxylic acids in the presence of pyridine, diisopropylcarbodiimide, and acetonitrile.
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 5502, 1989 DOI: 10.1021/jo00284a022
General Description
Pentafluorophenol is widely used as a precursor in both solution and solid-phase peptide synthesis. It is also involved in the preparation of aromatic fluoro derivatives.
reaction suitability
reaction type: Addition Reactions
Safety Profile
scu-rat LD50:322 mg/kg IZSBAI 3,91,65
Purification Methods
Pentafluorophenol is a hygroscopic low melting solid not freely soluble in H2O. Purify it by distillation, preferably in a vacuum [Forbes et al. J Chem Soc 2019 1959, IR and pKa: Birchall & Haszeldine J Chem Soc 13 1959]. IRofafilmhas max 3600 (OH) and 1575 (fluoroaromatic breathing) cm-1 . The benzoyl derivative has m 74-75o, 3,4-dinitrobenzoyl derivative has m 107o, the tosylate has m 64-65o (from EtOH) and the K salt crystallises from Me2CO, m 242o(dec), with 1H2O-salt the m is 248o(dec) and the 2H2O-salt has m 245o(dec). [Beilstein 6 IV 782.]
Pentafluorophenol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qi-Chem Co., Ltd. | +86-0411-88165951 +8613591335396 | marketing@qi-chem.com | China | 133 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12806 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20233 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19843 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Dongfan Chem. Co., Ltd. | 021-34500607 13391355195 | sales@dfanchem.com | CHINA | 61 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
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View Lastest Price from Pentafluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Pentafluorophenol
771-61-9
|
US $0.00-0.00 / Kg/Drum | 1KG | 99% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-28 | Pentafluorophenol
771-61-9
|
US $6.00 / kg | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd | |
 |
2025-04-23 | Pentafluorophenol
771-61-9
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Pentafluorophenol
771-61-9
- US $0.00-0.00 / Kg/Drum
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Pentafluorophenol
771-61-9
- US $6.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd
-
- Pentafluorophenol
771-61-9
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd