Nimesulide | 51803-78-2

Nimesulide Properties

Melting point	140-146°C
Boiling point	442.0±55.0 °C(Predicted)
Density	1.451±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form	Solid
pka	pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
color	Light orange to Yellow to Green
Water Solubility	Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax	391nm(H2O)(lit.)
Merck	14,6548
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference	51803-78-2(CAS DataBase Reference)
FDA UNII	V4TKW1454M
ATC code	M01AX17,M02AA26
EPA Substance Registry System	Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

3

RTECS

PB0970000

HS Code

2935.90.9500

HazardClass

6.1

PackingGroup

III

Toxicity

LD50 orally in rats: 324 mg/kg (Swingle, Moore)

NFPA 704

	0
2		0

Nimesulide price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N1016	Nimesulide	51803-78-2	1g	$30.7	2024-03-01	Buy
Sigma-Aldrich	N1016	Nimesulide	51803-78-2	5g	$109	2024-03-01	Buy
TCI Chemical	N0984	Nimesulide >98.0%(HPLC)(T)	51803-78-2	1g	$20	2024-03-01	Buy
TCI Chemical	N0984	Nimesulide >98.0%(HPLC)(T)	51803-78-2	5g	$53	2024-03-01	Buy
Alfa Aesar	J63699	Nimesulide	51803-78-2	5g	$53.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
N1016	1g	$30.7	Buy
N1016	5g	$109	Buy
N0984	1g	$20	Buy
N0984	5g	$53	Buy
J63699	5g	$53.65	Buy

Nimesulide Chemical Properties,Uses,Production

Description

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC₅₀s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC₅₀s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B⁰AT1) with an IC₅₀ value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E₂ (PGE₂; ) levels, as well as reduces pyresis (ED₅₀ = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Originator

Riker (USA)

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Definition

ChEBI: Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene.

brand name

Nimulid.

General Description

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.

Biochem/physiol Actions

Highly selective cyclooxygenase-2 inhibitor.

Clinical Use

Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Nimesulide Preparation Products And Raw materials

Raw materials

Organic base Ethanol Diphenyl ether Methanesulfonyl chloride Bromobenzene

Dichloromethane Acetic acid 4-Nitro-2-phenoxyaniline (2-PHENOXY)METHYLSULFONYLANILINE N-(2-Hydroxy-4-nitrophenyl)-phtalimide

2-Amino-5-nitrophenol

1of3

Preparation Products

Nimesulide Suppliers

Global( 568)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8812	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	232	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	193	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	295	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hangzhou Hyper Chemicals Limited	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58

View Lastest Price from Nimesulide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Nimesulide 51803-78-2	US $0.00 / Kg/Drum	25KG	98%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-20	Nimesulide 51803-78-2	US $1.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-11-19	Nimesulide 51803-78-2	US $30.00-50.00 / mg		99.91%	10g	TargetMol Chemicals Inc.

Nimesulide
51803-78-2
US $0.00 / Kg/Drum
98%
WUHAN FORTUNA CHEMICAL CO., LTD

Nimesulide
51803-78-2
US $1.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Nimesulide
51803-78-2
US $30.00-50.00 / mg
99.91%
TargetMol Chemicals Inc.

Nimesulide Spectrum

Nimesulide(51803-78-2)¹HNMR

51803-78-2(Nimesulide)Related Search:

Ethanesulfonamide Methyltrimethoxysilane Methanesulfonamide Dimethyldimethoxysilane N-Methyl methanesulfonamide

1-Phenyl-2-nitropropene 2-Methylbenzene-1-sulfonamide Methyltriethoxysilane Dimethyl sulfone Chlorodimethylphenylsilane

4-Methoxyphenylacetone Diphenyldimethoxysilane nitrotoluene NITROGEN DIOXIDE 2-Methoxy-4-nitroaniline

3-PHENOXYANILINE Cetirizine dihydrochloride N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE

1of4

nimed 4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD) CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD) CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD) 4-Nitro-2-phenoxymethanesulfonamide Nide Nidol Nisuli Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE(NIMESULIDE) MESULID AULIN FANSIDOL Nimesulide,N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide Nimesulide for peak identification Lizepat 4-Nitro-2-(phenoxy-d5) MethanesulfonaMide-d5 4'-Nitro-2'-(phenoxy-d5)Methanesulfonanilide Aulin-d5 Flogovital-d5 Lizepat-d5 N-(4-Nitro-2-(phenoxy-d5)phenyl)MethanesulfonaMide sulidene Nisulid N-(4-NITRO-2-PHENOXY)METHANESULFONANILIDE NIMESULIDE R-805 4’-nitro-2’-phenoxy-methanesulfonanilid 4-nitro-2-phenoxy-methanesulfonanilide flogovital n-(4-nitro-2-phenoxyphenyl)-methanesulfonamid Aufin N-(4-Nitro-2-phenoxyphenyl)methanesulphonamide Nimesulide > Nimesulide for peak identification CRS Nimesulide CRS Nimesulide USP/EP/BP Nimesulide (R805) Nimesulli Nimesulide, GR Nimesulide (N0845000) Nimesulide for peak identification (Y0001237) NimesulideQ: What is Nimesulide Q: What is the CAS Number of Nimesulide Q: What is the storage condition of Nimesulide N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE Nimesulide-d5 MESULID Powder USP Standard nimesulin Nimesulide (BP) 4'-Hydroxy Nimesulide-d4 Nimesulide in Acetonitrile 51803-78-2 74110-35-9 C13H7N2O5SD5 C13H7D5N2O5S Cell Signaling Enzymes BioChemical Application Index