ChemicalBook >> CAS DataBase List >>UNC8153 TFA
UNC8153 TFA
- CAS No.
- 2929304-61-8
- Chemical Name:
- UNC8153 TFA
- Synonyms
- UNC8153 TFA;UNC8153 (trifluoroacetate salt);2H-1,4-Benzoxazine-7-carboxamide, N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-, 2,2,2-trifluoroacetate (1:1)
- CBNumber:
- CB013812898
- Molecular Formula:
- C33H37N5O5.C2HF3O2
- Molecular Weight:
- 697.7
- MDL Number:
- MOL File:
- 2929304-61-8.mol
Last updated:2025-04-18 09:51:26
UNC8153 TFA Chemical Properties,Uses,Production
Uses
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
References
[1] Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188. DOI:10.1021/jacs.3c01421
UNC8153 TFA Preparation Products And Raw materials
Raw materials
Preparation Products
UNC8153 TFA Suppliers
Global( 13)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2980 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10499 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 10000 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 391 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24641 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5237 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd | 18502726233; 18502726233 | 3641133981@qq.com | China | 9713 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 2665 | 58 |
UNC8153 TFA
2H-1,4-Benzoxazine-7-carboxamide, N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-, 2,2,2-trifluoroacetate (1:1)
UNC8153 (trifluoroacetate salt)
2929304-61-8