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ChemicalBook >> CAS DataBase List >>(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Structure
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one structure
CAS No.
85175-59-3
Chemical Name:
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
Synonyms
7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;-2-one;Ivabradin-1;Ivabradine Impurity f;Ivabradine Impurity c;Ivabradine Impurity 64;Ivabradine intermediate2;(Z)-3-(3-chloropropyl)-7
CBNumber:
CB01509856
Molecular Formula:
C15H18ClNO3
Molecular Weight:
295.76
MDL Number:
MFCD09955404
MOL File:
85175-59-3.mol
MSDS File:
SDS
Last updated:2024-05-24 15:44:31
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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Properties

Melting point 100-102 °C(Solv: ethanol (64-17-5))
Boiling point 484.1±45.0 °C(Predicted)
Density 1.191±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka -1.23±0.20(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Signal word  Danger
Hazard statements  H332-H312-H302
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
HS Code  29339900

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C377615 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one 85175-59-3 250mg $80 2021-12-16 Buy
TRC C377615 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one 85175-59-3 5g $645 2021-12-16 Buy
Biosynth Carbosynth FC151724 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one 85175-59-3 50mg $704 2021-12-16 Buy
American Custom Chemicals Corporation HCH0037471 3-(3-CHLORO-PROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-BENZO[D]AZEPIN-2-ONE 95.00% 85175-59-3 5G $909.56 2021-12-16 Buy
Biosynth Carbosynth FC151724 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one 85175-59-3 2mg $59 2021-12-16 Buy
Product number Packaging Price Buy
C377615 250mg $80 Buy
C377615 5g $645 Buy
FC151724 50mg $704 Buy
HCH0037471 5G $909.56 Buy
FC151724 2mg $59 Buy

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Chemical Properties,Uses,Production

synthetic

1.5g (6.8mmol) of 7,8-dimethoxy-1,3-dihydro-2h-3-benzoaza-2-one, 1.5g (9.5mmol) of 1,3-bromochloropropane and 6ml of DMF into a flask, raise the temperature of the mixture to 40 ℃, and add 0.8g of 40% sodium hydroxide (8mmol) solution. The mixture was then heated to 60 ° C and stirred for 2 hours; Add 30 ml of ice water and stir for 1 hour under the cooling of ice water bath. Filter out solid precipitates, wash and dry. The yield of the title compound was 85%.
Synthesis of 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one

Description

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is the side chain of ivabradine hydrochloride. Ivabradine and its medicinal salts, especially its hydrochloride, have very important pharmacological and therapeutic properties, especially, in slowing down the heart rate. Relating compounds can be used to treat or prevent various clinical myocardial ischemia conditions, such as angina pectoris, myocardial infarction and related rhythm disorders, various pathologies involving rhythm disorders, especially supraventricular rhythm disorders.

Uses

3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.

Uses

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one is an organic compound which can be used as pharmaceutical intermediates.

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one synthesis

73942-87-7
109-70-6
85175-59-3
Synthesis of (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one and 1-Bromo-3-chloropropane

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Preparation Products And Raw materials

Raw materials

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 1-Bromo-3-chloropropane

Preparation Products

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one

(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Suppliers

Global( 234)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.
+undefined-0518-86098006 +undefined19851887368 lvan.hui@jsytsw.com China 80 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18777 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9210 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29882 58
Ningbo Nuobai Pharmaceutical Co., Ltd. 		18758416982 Fisheryu@nbpharm.com China 13 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +8615064153060 sales01@jndxj.com China 291 58
Supplier Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Ningbo Nuobai Pharmaceutical Co., Ltd. 		58
Anhui Dexinjia Biopharm Co., Ltd 		58

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View Lastest Price from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one pictures 2024-10-25 (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
85175-59-3
 US $50.00 / kg 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one pictures 2023-07-19 (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
85175-59-3
 US $30.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) pictures 2023-03-10 (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)
85175-59-3
 US $39.00 / KG 1KG 99% 5 Tons Per Day Weijer International Trade (Hebei) Co., Ltd.

85175-59-3((Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one)Related Search:

3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one 7-DeMethyl Ivabradine 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one N-DeMethyl Ivabradine Hydrochloride 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one)
C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE (3,4-Dimethoxyphenyl)acetic acid Hydroxy Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 8-DeMethyl Ivabradine
3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 4,5-Dimethoxy-1-cyanobenzocyclobutane
Ivabradine Impurity 70 1204612-29-2 3,4-dimethoxy-N-methylbenzamide

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(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one ,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azepin-2-one 3-(3-chloropropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one 3-(3-Chloropropyl)-7,8-diMethoxy-1H-3-benzazepin-2(3H)-one 2H-3-Benzazepin-2-one, 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy- 3-(3-Chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3- 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-Benzazepin-2-one(For Ivabradine) Ivabradine Impurity c Ivabradine Impurity f 3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one 3-(3-chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-onezazepin-2-one Ivabradine intermediate2 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-be Ivabradine related compound 4 Ivabradin-1 (Z)-3-(3-chloropropyl)-7 8-diethyl-1H-benzo[d] azepin-2 (3H)-one Ivabradine Impurity 64 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one AZEPIN-2 (3H) - (Z) -3- (3-chloropropyl) -7, 8-diethyl-1H - benzo [D] azepin-2 (3H) - (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H) 3-(3-CHLOROPROPYL)-7,8-DIMETHOXY- 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one 3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one 8-Demethyl Ivabradine Intermediate（Ivabradine Impurity 8） (S)-3,3'-((((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)azanediyl)bis(propane-3,1-diyl))bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) 3-(3-Chloropropyl)-7,8-dimethoxy-2,3-dihydro-1H-benzoazepin-2-one -2-one 3-(3-Chloropropyl)-7,8-dimetho​ xy-1,3-dihydro-2H-3-benzazepin​ Ivabradine chloro Impurity 3-(3-chloropropy)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one 85175-59-3