ANTI-SIR2 (AS-16) RABBIT
- CAS No.
- Chemical Name:
- ANTI-SIR2 (AS-16) RABBIT
- Synonyms
- ANTI-SIR2 (AS-16) RABBIT;Anti-Sir2 (AS-16) antibody produced in rabbit
- CBNumber:
- CB0167738
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03792039
- MOL File:
- Mol file
ANTI-SIR2 (AS-16) RABBIT price More Price(1)
ANTI-SIR2 (AS-16) RABBIT Chemical Properties,Uses,Production
Uses
Anti-Sir2 (AS-16) antibody produced in rabbit has been used in
- western blotting
- immunoprecipitation
- antibody microarray
General Description
Sir2 belongs to a family of proteins that is found in organisms ranging from bacteria to complex eukaryotes. Members of this family contain a 250 amino acid core domain that shares about 25-60% sequence identity.
Biochem/physiol Actions
Sir2, one of the silent information regulator genes, encodes a protein that promotes a compact chromatin structure, thereby preventing or silencing gene transcription at selected loci. Silencing occurs as a series of events initiated by formation of Sir complexes (Sir2, Sir3, Sir4). Sir2 protein is an NAD-dependent histone deacetylase. Sir2 transfers acetyl groups from its protein substrates to ADP-ribose and synthesizes o-acetyl ADP-ribose. Through histone deacetylation, Sir2 may silence chromatin. It appears that Sir2 NAD requirement makes this protein an important player in the pathway that leads to increased life span of several species through calorie restriction.
ANTI-SIR2 (AS-16) RABBIT Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-SIR2 (AS-16) RABBIT Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Riedel-de Haen AG | -- | United States | 6825 | 87 | |
SIGMA-RBI | -- | Switzerland | 6913 | 91 |
Supplier | Advantage |
---|---|
Riedel-de Haen AG | 87 |
SIGMA-RBI | 91 |