TRIFORINE | 26644-46-2

TRIFORINE Properties

Melting point	155℃ (decomposition)
Boiling point	561.5±50.0 °C(Predicted)
Density	1.5269 (rough estimate)
vapor pressure	8 x 10^-2 Pa (25 °C)
refractive index	1.6000 (estimate)
storage temp.	0-6°C
solubility	DMSO (Slightly)
pka	10.6 (base)
Water Solubility	9 mg l^-1 (20 °C)
color	White to Off-White
Merck	13,9762
BRN	626358
CAS DataBase Reference	26644-46-2
FDA UNII	N1A4W8U0HH
Proposition 65 List	Triforine
Pesticides Freedom of Information Act (FOIA)	Triforine
EPA Substance Registry System	Triforine (26644-46-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332
Precautionary statements	P261-P271-P304+P340+P312
Hazard Codes	Xn
Risk Statements	52/53-20
Safety Statements	61
RIDADR	UN3077 (solid); UN3082 (liquid)
WGK Germany	2
RTECS	TK9200000
Toxicity	LD50 oral in rat: 6gm/kg

TRIFORINE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	45701	Triforin PESTANAL	26644-46-2	250mg	$84	2024-03-01	Buy
TRC	T793655	Triforin	26644-46-2	25mg	$95	2021-12-16	Buy

Product number	Packaging	Price	Buy
45701	250mg	$84	Buy
T793655	25mg	$95	Buy

TRIFORINE Chemical Properties,Uses,Production

Description

Triforine is a clear light yellow colour with an ethanol (alcohol) odour and a highly flammable liquid. It is used as a fungicide for the control of black spot, powdery mildew, and diseases of rust in roses, fruits, vegetables, cereals, and ornamentals. Application of triforine acts both as a preventative and a curative fungicide and is known to destroying diseases already in the plant and also preventing disease infestations. It is also used as a post-harvest control of brown rot on peaches, nectarines, apricots, cherries, and plums.

Uses

This pesticide is widely used in flower growing. Cross reactions are expected to diehlorvos.

Uses

food additive; fungicide; agricultural chemical.

Uses

Triforine is used to control powdery mildews on cereals, fruits, vines, hops, ornamentals, cucurbits and some vegetables, rusts on cereals, fruit, ornamentals and beans. It also controls Munilia spp. on stone fruit, Ascochyta blight on chrysanthemums, black spot on roses, scab on apples and fairy rings on turf. Triforine also suppresses tetranychid mite activity.

Definition

ChEBI: A member of the class of N-alkylpiperazines in which the two amino groups of piperazine are replaced by 1-formamido-2,2,2-trichloroethyl groups. A fungicide active against a range of diseases including powdery mildew, scab and rust.

General Description

Colorless crystals. Non corrosive. Used as a fungicide.

Reactivity Profile

A piperazine, trichloromethylformamide derivative. Decomposed in strong acid to trichloroacetaldehyde and piperazine salts, and in strongly alkaline media to chloroform and piperazine.

Hazard

Low toxicity by ingestion, inhalation, and skin contact. Human systemic effects.

Agricultural Uses

Fungicide: Triforine is a systemic fungicide with protectant, eridicant, and curative activity. It is locally systemic, is quickly absorbed by the plant and should be applied on or before an infection occurs. Triforine is used for control of black spot, brown rot, scab, petal blight, rust and other diseases on fruits such as apples, peaches, plumbs, nectarines, apricots, and strawberry; in hops, vegetables, cereals, and ornamentals such as roses and chrysanthemums. Triforine breaks down rapidly in the environment. Not approved for use in EU countries . Registered for use in the U.S.

Trade name

CELA50®; CW524®; DENARIN® FUNGINEX®; SAPROL®; TRIFORIN®; W524®

Contact allergens

This pesticide is widely used in flower growing. Cross- reactions are expected to dichlorvos.

Safety Profile

Low toxicity by ingestion, inhalation, and skin contact. Human systemic effects: change in taste function. When heated to decomposition emits toxic fumes of NOx and Cl-.

Metabolic pathway

Thermal reaction of triforine with several alcohols in a closed glass tube gives N-(1-alkoxy-2,2,2- trichloroethyl) formamides.

Degradation

Triforine (1) is stable up to 180°C. It decomposes in aqueous solution when exposed to daylight or UV light. In strongly acid media, it is decomposed to trichloroacetaldehyde and piperazine salts. In strongly basic media, triforine decomposes to give chloroform and piperazine (DT₅₀ 3.5 days at pH 5-7, 25 °C). From an unbuffered aqueous solution stored for 13 weeks, four hydrolysis products of triforine, 5, 6, 7 and 3, were isolated by preparative thin-layer chromatography. After 6 months at room temperature in an unbuffered solution, 7 was the major product. These products indicate that stepwise removal of substituents from the nitrogen atoms of the ring occurred and the composition of the mixtures produced by hydrolysis was shown to be pH- and time-dependent (Scheme 1).
When solid triforine was irradiated with UV light (254 nm) for 1, 16 or 64 hours, analysis of the products showed that one side chain was removed preferentially and the second was attacked more slowly.
Products 2, 3, 4 [N-(2,2-dichlorovinyl)formamide], 12 (probably formed by reaction of 2 with chloral, a photoproduct) and 2,2,2-trichloroethane- 1,1-diol were identified and minor amounts of six other products were detected by thin-layer chromatography. Compound 2 is probably the major photolytic product. When triforine was irradiated in solution in deionised water with a quartz high pressure lamp (maximum energy at 366 nm), 4 was isolated and identified as a product of photolysis but was itself photolabile and could no longer be detected after 5 hours irradiation (Darda et al., 1977).

TRIFORINE Preparation Products And Raw materials

Raw materials

Chloral Triethylamine Piperazine 1,4-Dioxane Magnesium sulfate

Thionyl chloride

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Preparation Products

TRIFORINE Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18153	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	sales@senfeida.com	China	23046	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Hebei Fengmu Trading Co., Ltd.	+8613393234347	Lyla@fengmuchem.com	China	2948	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
LEAP CHEM CO., LTD.	58
Hebei Weibang Biotechnology Co., Ltd	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Hebei Fengmu Trading Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
J & K SCIENTIFIC LTD.	76

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SAPROL SAPROL(R) N,N'-[PIPERAZINE-1,4-DIYLBIS(TRICHLOROMETHYL)METHYLENE]-DIFORMAMIDE PIPERAZIN-1,4-DIYL-BIS-[1-(2,2,2-TRICHLOROETHYL)FORMAMIDE] TRIFORIN TRIFORINE 1,4-bis(1-formamido-2,2,2-trichloroethyl)-piperazin 1,4-bis(1-formamido-2,2,2-trichloroethyl)piperazine biformychlorazin biformylchlorazin ca70203 w524 CELA W524 DENARIN(R) FUNDINEX(R) FUNGINEX Denarin(Cela Merck) TRIFORIN PESTANAL, 250 MG TRIFORINE, 100M, NEAT Formamide, N,N-1,4-piperazinediylbis(2,2,2-trichloroethylidene)bis- triforine (bsi,iso,ansi,jmaf) 1，4-di(2,2,2-trichloro-1-formamidoethyl) piperazine N,N'-[Piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]bisformamide 1,4-BIS(2,2,2-TRICHLORO-1-FORMAMIDOETHYL)-PIPERAZINE Denarin cela50 cme74770 cw524 n,n’-(1,4-piperazinediylbis(2,2,2-trichloroethylidene))bis-formamid n,n’-(piperazinediylbis(2,2,2-trichloroethylidene))bis(formamide) N,N’-[1,4-Piperazinediylbis(2,2,2-trichloro-ethylidene)]-bisformamide n,n’-bis(1-formamido-2,2,2-trichloroethyl)piperazine Triforine 100mg [26644-46-2] 1,4-Bis(2,2,2-trichoro-1-formamidoethyl)piperazine Asepta Funginex NSC 263493 Triforine 0.25 Triforine Solution, 1000ppm Triforine @100 μg/mL in MeOH Triforine Standard (mixture of isomers) riforine Benzoylprop-ethyl Impurity 15 N,N'-(piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl))diformamide Triforine 10 μg/ml Acetonitrile Triforine 100 μg/ml Acetonitrile Triforine in Acetonitrile 26644-46-2 26644462 C10H14Cl6N4O2 Amide structureAlphabetic Fungicides Pesticides TP - TZ Alpha sort Amide structurePesticides&Metabolites Q-ZAlphabetic